Calcipotriol/betamethasone for the treatment of psoriasis: efficacy, safety, and patient acceptability
Christina RogalskiMedical Business Development, edia.con gemeinnützige GmbH, Leipzig, Saxony, GermanyBackground: One of the advances in the treatment of plaque-type psoriasis is combined local therapy with calcipotriol and betamethasone. To provide both ingredients in a two-compound product...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-06-01
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| Series: | Psoriasis: Targets and Therapy |
| Online Access: | http://www.dovepress.com/calcipotriolbetamethasone-for-the-treatment-of-psoriasis-efficacy-safe-peer-reviewed-article-PTT |
| _version_ | 1818751168252215296 |
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| author | Rogalski C |
| author_facet | Rogalski C |
| author_sort | Rogalski C |
| collection | DOAJ |
| description | Christina RogalskiMedical Business Development, edia.con gemeinnützige GmbH, Leipzig, Saxony, GermanyBackground: One of the advances in the treatment of plaque-type psoriasis is combined local therapy with calcipotriol and betamethasone. To provide both ingredients in a two-compound product, efforts have been made to unite calcipotriol and betamethasone because they are usually inactivated when present in the same formulation. This aspect was resolved when carefully designed vehicle components were invented (gel and ointment). This article reviews the efficacy, safety, and patient acceptability of calcipotriol/betamethasone dipropionate.Methods: A literature search of all articles published until February 2015 was performed, including the largest medical databases. The search strategy for evaluating the main topics of this review – efficacy, safety, and patient acceptability – was defined before checking the publications.Results: Seventy references were found and checked for relevance. For efficacy, the proportion of patients whose psoriasis improved was always significantly higher in the two-compound group compared to the group treated with the individual substances. In the context of safety, the fixed combination was generally associated with a lower risk of adverse events. In terms of patient acceptability, the fixed combination led to a significant improvement in quality of life. The two-compound product was more convenient to handle and time saving compared to former treatments.Conclusion: Calcipotriol/betamethasone dipropionate in a fixed combination is an effective and well-tolerated medication in mild-to-moderate psoriasis of body and scalp and, in addition, is an evidence-based treatment modality.Keywords: psoriasis, calcipotriol/betamethasone, safety, efficacy, fixed combination, two-compound medication |
| first_indexed | 2024-12-18T04:31:17Z |
| format | Article |
| id | doaj.art-e8817301c9ba4248b8262399ef62c6be |
| institution | Directory Open Access Journal |
| issn | 2230-326X |
| language | English |
| last_indexed | 2024-12-18T04:31:17Z |
| publishDate | 2015-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Psoriasis: Targets and Therapy |
| spelling | doaj.art-e8817301c9ba4248b8262399ef62c6be2022-12-21T21:20:59ZengDove Medical PressPsoriasis: Targets and Therapy2230-326X2015-06-012015default9710722075Calcipotriol/betamethasone for the treatment of psoriasis: efficacy, safety, and patient acceptabilityRogalski CChristina RogalskiMedical Business Development, edia.con gemeinnützige GmbH, Leipzig, Saxony, GermanyBackground: One of the advances in the treatment of plaque-type psoriasis is combined local therapy with calcipotriol and betamethasone. To provide both ingredients in a two-compound product, efforts have been made to unite calcipotriol and betamethasone because they are usually inactivated when present in the same formulation. This aspect was resolved when carefully designed vehicle components were invented (gel and ointment). This article reviews the efficacy, safety, and patient acceptability of calcipotriol/betamethasone dipropionate.Methods: A literature search of all articles published until February 2015 was performed, including the largest medical databases. The search strategy for evaluating the main topics of this review – efficacy, safety, and patient acceptability – was defined before checking the publications.Results: Seventy references were found and checked for relevance. For efficacy, the proportion of patients whose psoriasis improved was always significantly higher in the two-compound group compared to the group treated with the individual substances. In the context of safety, the fixed combination was generally associated with a lower risk of adverse events. In terms of patient acceptability, the fixed combination led to a significant improvement in quality of life. The two-compound product was more convenient to handle and time saving compared to former treatments.Conclusion: Calcipotriol/betamethasone dipropionate in a fixed combination is an effective and well-tolerated medication in mild-to-moderate psoriasis of body and scalp and, in addition, is an evidence-based treatment modality.Keywords: psoriasis, calcipotriol/betamethasone, safety, efficacy, fixed combination, two-compound medicationhttp://www.dovepress.com/calcipotriolbetamethasone-for-the-treatment-of-psoriasis-efficacy-safe-peer-reviewed-article-PTT |
| spellingShingle | Rogalski C Calcipotriol/betamethasone for the treatment of psoriasis: efficacy, safety, and patient acceptability Psoriasis: Targets and Therapy |
| title | Calcipotriol/betamethasone for the treatment of psoriasis: efficacy, safety, and patient acceptability |
| title_full | Calcipotriol/betamethasone for the treatment of psoriasis: efficacy, safety, and patient acceptability |
| title_fullStr | Calcipotriol/betamethasone for the treatment of psoriasis: efficacy, safety, and patient acceptability |
| title_full_unstemmed | Calcipotriol/betamethasone for the treatment of psoriasis: efficacy, safety, and patient acceptability |
| title_short | Calcipotriol/betamethasone for the treatment of psoriasis: efficacy, safety, and patient acceptability |
| title_sort | calcipotriol betamethasone for the treatment of psoriasis efficacy safety and patient acceptability |
| url | http://www.dovepress.com/calcipotriolbetamethasone-for-the-treatment-of-psoriasis-efficacy-safe-peer-reviewed-article-PTT |
| work_keys_str_mv | AT rogalskic calcipotriolbetamethasoneforthetreatmentofpsoriasisefficacysafetyandpatientacceptability |