Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrel
Zuzana Motovska, Petr WidimskyThird Medical Faculty of Charles University and University Hospital Kralovske Vinohrady, Prague, Czech RepublicAbstract: Dual oral antiplatelet therapy, aspirin plus thienopyridine, has permitted a rapid increase in the use of coronary intervention procedures. Clopidogr...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2009-05-01
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| Series: | Vascular Health and Risk Management |
| Online Access: | http://www.dovepress.com/improving-outcomes-in-patients-undergoing-percutaneous-coronary-interv-a3157 |
| _version_ | 1818676857334136832 |
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| author | Zuzana Motovska Petr Widimsky |
| author_facet | Zuzana Motovska Petr Widimsky |
| author_sort | Zuzana Motovska |
| collection | DOAJ |
| description | Zuzana Motovska, Petr WidimskyThird Medical Faculty of Charles University and University Hospital Kralovske Vinohrady, Prague, Czech RepublicAbstract: Dual oral antiplatelet therapy, aspirin plus thienopyridine, has permitted a rapid increase in the use of coronary intervention procedures. Clopidogrel is the thienopyridine of choice for dual antiplatelet therapy in patients treated with percutaneous coronary intervention. However, there are two issues with clopidogrel: (1) clopidogrel’s antiplatelet activity is delayed because the drug needs to be metabolized into its active form and (2) variability in patient response to clopidogrel has been demonstrated. To overcome these shortcomings of clopidogrel, new more potent inhibitors of P2Y12 receptors, which have a more rapid onset of action have been introduced for clinical evaluation. This article is a nonexhaustive review of the literature and concentrates on prasugrel, a third-generation, oral thienopyridine. The purpose is to summarize the current knowledge about the benefits and risks of prasugrel and to outline the most prudent strategies for the drug’s clinical use.Keywords: P2Y12 receptors, prasugrel, oral thienopyridine, dual oral antiplatelet therapy |
| first_indexed | 2024-12-17T08:50:08Z |
| format | Article |
| id | doaj.art-e8825c8ded7746a487d6363f44a6b199 |
| institution | Directory Open Access Journal |
| issn | 1176-6344 1178-2048 |
| language | English |
| last_indexed | 2024-12-17T08:50:08Z |
| publishDate | 2009-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-e8825c8ded7746a487d6363f44a6b1992022-12-21T21:56:07ZengDove Medical PressVascular Health and Risk Management1176-63441178-20482009-05-012009default475481Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrelZuzana MotovskaPetr WidimskyZuzana Motovska, Petr WidimskyThird Medical Faculty of Charles University and University Hospital Kralovske Vinohrady, Prague, Czech RepublicAbstract: Dual oral antiplatelet therapy, aspirin plus thienopyridine, has permitted a rapid increase in the use of coronary intervention procedures. Clopidogrel is the thienopyridine of choice for dual antiplatelet therapy in patients treated with percutaneous coronary intervention. However, there are two issues with clopidogrel: (1) clopidogrel’s antiplatelet activity is delayed because the drug needs to be metabolized into its active form and (2) variability in patient response to clopidogrel has been demonstrated. To overcome these shortcomings of clopidogrel, new more potent inhibitors of P2Y12 receptors, which have a more rapid onset of action have been introduced for clinical evaluation. This article is a nonexhaustive review of the literature and concentrates on prasugrel, a third-generation, oral thienopyridine. The purpose is to summarize the current knowledge about the benefits and risks of prasugrel and to outline the most prudent strategies for the drug’s clinical use.Keywords: P2Y12 receptors, prasugrel, oral thienopyridine, dual oral antiplatelet therapyhttp://www.dovepress.com/improving-outcomes-in-patients-undergoing-percutaneous-coronary-interv-a3157 |
| spellingShingle | Zuzana Motovska Petr Widimsky Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrel Vascular Health and Risk Management |
| title | Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrel |
| title_full | Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrel |
| title_fullStr | Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrel |
| title_full_unstemmed | Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrel |
| title_short | Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrel |
| title_sort | improving outcomes in patients undergoing percutaneous coronary intervention role of prasugrel |
| url | http://www.dovepress.com/improving-outcomes-in-patients-undergoing-percutaneous-coronary-interv-a3157 |
| work_keys_str_mv | AT zuzanamotovska improvingoutcomesinpatientsundergoingpercutaneouscoronaryinterventionroleofprasugrel AT petrwidimsky improvingoutcomesinpatientsundergoingpercutaneouscoronaryinterventionroleofprasugrel |