In vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans
The objective was to evalúate the in vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans. It was an experimental study, 54 experimental units were used (9 poison concentrations, 2 strains and three repetitions). Th...
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| Format: | Article |
| Language: | Spanish |
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Selva Andina Research Society
2019-08-01
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| Series: | Journal of the Selva Andina Research Society |
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| Online Access: | http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S2072-92942019000200004&lng=es&nrm=iso&tlng=es |
| _version_ | 1830188850478055424 |
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| author | Rivera-Coronado Nileth Daysy Pérez-Delgado Orlando |
| author_facet | Rivera-Coronado Nileth Daysy Pérez-Delgado Orlando |
| author_sort | Rivera-Coronado Nileth Daysy |
| collection | DOAJ |
| description | The objective was to evalúate the in vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans. It was an experimental study, 54 experimental units were used (9 poison concentrations, 2 strains and three repetitions). The venom of the scorpion was obtained by electrical stimulation. The double serial dilution method was determined at different concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%, 0.39%. To evalúate the antifungal activity, the microdilution method was used to determine the Mínimum Inhibitory Concentration (MIC). The results showed that by means of the microdilution method that for the strain n ° 1 presented a mínimum inhibitory concentration (MIC) to 25% of the diluted raw venom, very different was for the strain n ° 2 did not present CMI. It was concluded that the fmdings of the current study show that the diluted crude extract of the scorpion venom H. charcasus possesses antifungal activity on strains of C. albicans, being possible to use it as a témplate for the design and development of new antifungal drugs. |
| first_indexed | 2024-12-17T22:51:58Z |
| format | Article |
| id | doaj.art-e883dff97de545ce8a18f086d59617e4 |
| institution | Directory Open Access Journal |
| issn | 2072-9294 2072-9308 |
| language | Spanish |
| last_indexed | 2024-12-17T22:51:58Z |
| publishDate | 2019-08-01 |
| publisher | Selva Andina Research Society |
| record_format | Article |
| series | Journal of the Selva Andina Research Society |
| spelling | doaj.art-e883dff97de545ce8a18f086d59617e42022-12-21T21:29:38ZspaSelva Andina Research SocietyJournal of the Selva Andina Research Society2072-92942072-93082019-08-0110296104https://doi.org/10.36610/J.JSARS.2019.100200096In vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicansRivera-Coronado Nileth Daysy0Pérez-Delgado Orlando1https://orcid.org/0000-0002-5849-1047Universidad Señor de Sipán. Facultad de Ciencias de la Salud. Escuela de Estomatología. Km 5 Carretera a Pimentel. Chiclayo-Perú. Dirección postal: 14001 Cel.+51934982007Universidad Católica Santo Toribio de Mogrovejo. Facultad de Medicina. Laboratorio de Microbiología. Av. San Josemaría Escrivá de Balaguer 855. Chiclayo-Perú. Dirección postal: 14001. Cel.+51985718100The objective was to evalúate the in vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans. It was an experimental study, 54 experimental units were used (9 poison concentrations, 2 strains and three repetitions). The venom of the scorpion was obtained by electrical stimulation. The double serial dilution method was determined at different concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%, 0.39%. To evalúate the antifungal activity, the microdilution method was used to determine the Mínimum Inhibitory Concentration (MIC). The results showed that by means of the microdilution method that for the strain n ° 1 presented a mínimum inhibitory concentration (MIC) to 25% of the diluted raw venom, very different was for the strain n ° 2 did not present CMI. It was concluded that the fmdings of the current study show that the diluted crude extract of the scorpion venom H. charcasus possesses antifungal activity on strains of C. albicans, being possible to use it as a témplate for the design and development of new antifungal drugs.http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S2072-92942019000200004&lng=es&nrm=iso&tlng=eshadruroides charcasuscandida albicansantifungalscorpion venom. |
| spellingShingle | Rivera-Coronado Nileth Daysy Pérez-Delgado Orlando In vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans Journal of the Selva Andina Research Society hadruroides charcasus candida albicans antifungal scorpion venom. |
| title | In vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans |
| title_full | In vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans |
| title_fullStr | In vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans |
| title_full_unstemmed | In vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans |
| title_short | In vitro antifungal activity of the diluted crude extract of the scorpion venom Hadruroides charcasus (Karsch 1879) against Candida albicans |
| title_sort | in vitro antifungal activity of the diluted crude extract of the scorpion venom hadruroides charcasus karsch 1879 against candida albicans |
| topic | hadruroides charcasus candida albicans antifungal scorpion venom. |
| url | http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S2072-92942019000200004&lng=es&nrm=iso&tlng=es |
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