Andexanet alpha-induced heparin resistance treated by nafamostat mesylate in a patient undergoing total aortic arch repair for Stanford type A acute aortic dissection: a case report

Andexanet alpha-induced heparin resistance treated by nafamostat mesylate in a patient undergoing total aortic arch repair for Stanford type A acute aortic dissection: a case report

Abstract Background Andexanet alfa, an anti-Xa inhibitor antagonist, induces heparin resistance. Here, we report a case of successful management of cardiopulmonary bypass with andexanet alfa-induced heparin resistance using nafamostat mesylate. Case presentation An 84-year-old female, with Stanford...

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Bibliographic Details
Main Authors: Yasuhito Suzuki, Mutsuhito Kikura, Shingo Kawashima, Tetsuro Kimura, Yoshiki Nakajima
Format: Article
Language:English
Published: SpringerOpen 2024-01-01
Series:JA Clinical Reports
Subjects:
Andexanet alpha
Oral Xa inhibitor
Direct oral anticoagulants
Heparin resistance
Nafamostat mesylate
Antithrombin
Online Access:https://doi.org/10.1186/s40981-024-00690-8

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