SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485

SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485

Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 (SIRT1) and AMP‐activated protein kinase (AMPK) were previously reported to modulate vascular senescence; however, its effects h...

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Bibliographic Details
Main Authors: Jin Young Sung, Seul Gi Kim, Du Hyong Cho, Jae‐Ryong Kim, Hyoung Chul Choi
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:FEBS Open Bio
Subjects:
p‐AMPK (Ser485)
SIRT1
SRT1720
telomere length
VSMC senescence
Online Access:https://doi.org/10.1002/2211-5463.12895

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