Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

Herpes simplex virus-2 (HSV-2) is shed episodically, leading to occasional genital ulcers and efficient transmission. The biology explaining highly variable shedding patterns, in an infected person over time, is poorly understood. We sampled the genital tract for HSV DNA at several time intervals an...

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Bibliographic Details
Main Authors: Joshua T Schiffer, David Swan, Ramzi Al Sallaq, Amalia Magaret, Christine Johnston, Karen E Mark, Stacy Selke, Negusse Ocbamichael, Steve Kuntz, Jia Zhu, Barry Robinson, Meei-Li Huang, Keith R Jerome, Anna Wald, Lawrence Corey
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-04-01
Series:eLife
Subjects:
Herpes simplex
Mucosal immunity
Mathematical modeling
Online Access:https://elifesciences.org/articles/00288

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