Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis
Granulomatosis or eosinophilic granulomatosis with polyangiitis (GPA/EGPA) can affect multiple organs resulting in heterogeneous symptoms and phenotypes. Pituitary gland dysfunction rarely occurs in GPA (1–3%) and even less in EGPA (two case reports). Here, we report a case of a 51-year-old female p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-06-01
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| Series: | Therapeutic Advances in Neurological Disorders |
| Online Access: | https://doi.org/10.1177/17562864231182519 |
| _version_ | 1797796830959894528 |
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| author | Jessy Chen Tobias Alexander Thula Walter-Rittel Athanasia Ziagaki Volker Siffrin |
| author_facet | Jessy Chen Tobias Alexander Thula Walter-Rittel Athanasia Ziagaki Volker Siffrin |
| author_sort | Jessy Chen |
| collection | DOAJ |
| description | Granulomatosis or eosinophilic granulomatosis with polyangiitis (GPA/EGPA) can affect multiple organs resulting in heterogeneous symptoms and phenotypes. Pituitary gland dysfunction rarely occurs in GPA (1–3%) and even less in EGPA (two case reports). Here, we report a case of a 51-year-old female patient with a four-year history of EGPA who presented with new polydipsia and polyuria. Laboratory testing and magnetic resonance imaging (MRI) confirmed pituitary gland dysfunction caused by a hypophysitis. Therapeutic adjustment with a switch from dupilumab to mepolizumab resulted in a decrease in clinical symptoms, inflammation in MRI, and normalization of C-reactive protein in serum. This case underlines hypophysitis as a rare organ involvement also in EGPA. Moreover, this case demonstrates the responsiveness of neuroinflammatory manifestations to the recently approved anti-interleukin-5 monoclonal antibody mepolizumab as a new potential treatment option. |
| first_indexed | 2024-03-13T03:39:59Z |
| format | Article |
| id | doaj.art-e888b99cec054f3da9bf8e18b0a1fd11 |
| institution | Directory Open Access Journal |
| issn | 1756-2864 |
| language | English |
| last_indexed | 2024-03-13T03:39:59Z |
| publishDate | 2023-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Neurological Disorders |
| spelling | doaj.art-e888b99cec054f3da9bf8e18b0a1fd112023-06-23T11:33:34ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28642023-06-011610.1177/17562864231182519Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitisJessy ChenTobias AlexanderThula Walter-RittelAthanasia ZiagakiVolker SiffrinGranulomatosis or eosinophilic granulomatosis with polyangiitis (GPA/EGPA) can affect multiple organs resulting in heterogeneous symptoms and phenotypes. Pituitary gland dysfunction rarely occurs in GPA (1–3%) and even less in EGPA (two case reports). Here, we report a case of a 51-year-old female patient with a four-year history of EGPA who presented with new polydipsia and polyuria. Laboratory testing and magnetic resonance imaging (MRI) confirmed pituitary gland dysfunction caused by a hypophysitis. Therapeutic adjustment with a switch from dupilumab to mepolizumab resulted in a decrease in clinical symptoms, inflammation in MRI, and normalization of C-reactive protein in serum. This case underlines hypophysitis as a rare organ involvement also in EGPA. Moreover, this case demonstrates the responsiveness of neuroinflammatory manifestations to the recently approved anti-interleukin-5 monoclonal antibody mepolizumab as a new potential treatment option.https://doi.org/10.1177/17562864231182519 |
| spellingShingle | Jessy Chen Tobias Alexander Thula Walter-Rittel Athanasia Ziagaki Volker Siffrin Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis Therapeutic Advances in Neurological Disorders |
| title | Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis |
| title_full | Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis |
| title_fullStr | Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis |
| title_full_unstemmed | Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis |
| title_short | Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis |
| title_sort | mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis |
| url | https://doi.org/10.1177/17562864231182519 |
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