Optimizing cryopreservation conditions for use of fucosylated human mesenchymal stromal cells in anti-inflammatory/immunomodulatory therapeutics

Optimizing cryopreservation conditions for use of fucosylated human mesenchymal stromal cells in anti-inflammatory/immunomodulatory therapeutics

Mesenchymal stem/stromal cells (MSCs) are being increasingly used in cell-based therapies due to their broad anti-inflammatory and immunomodulatory properties. Intravascularly-administered MSCs do not efficiently migrate to sites of inflammation/immunopathology, but this shortfall has been overcome...

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Bibliographic Details
Main Authors: Jesús I. Gil-Chinchilla, Carlos Bueno, Carlos M. Martínez, Ana Ferrández-Múrtula, Ana M. García-Hernández, Miguel Blanquer, Mar Molina-Molina, Agustín G. Zapata, Robert Sackstein, Jose M. Moraleda, David García-Bernal
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stromal cells
exofucosylation
HCELL
E-selectin ligand
cryopreservation
immunomodulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1385691/full

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