Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein

Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein

Multidrug-Resistant (MDR) cancers attenuate chemotherapeutic efficacy through drug efflux, a process that transports drugs from within a cell to the extracellular space via ABC (ATP-Binding Cassette) transporters, including P-glycoprotein 1 (P-gp or ABCB1/MDR1). Conversely, Toll-Like Receptor (TLR)...

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Bibliographic Details
Main Authors: Anunay J. Pulukuri, Anthony J. Burt, Larissa K. Opp, Colin M. McDowell, Maryam Davaritouchaee, Amy E. Nielsen, Rock J. Mancini
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
Imiquimod
drug efflux
multidrug resistance
immunotherapy
Toll-Like Receptor
Online Access:https://www.mdpi.com/1424-8247/14/12/1292

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