Spatiotemporal Differentiation of MMN From N1 Adaptation: A Human ECoG Study
Auditory mismatch negativity (MMN) is an electrophysiological response to a deviation from regularity. This response is considered pivotal to understanding auditory processing, particularly in the pre-attentive phase. However, previous findings suggest that MMN is a product of N1 adaptation/enhancem...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00586/full |
| _version_ | 1818961408717488128 |
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| author | Megumi Takasago Naoto Kunii Misako Komatsu Mariko Tada Mariko Tada Kenji Kirihara Takanori Uka Yohei Ishishita Seijiro Shimada Kiyoto Kasai Kiyoto Kasai Nobuhito Saito |
| author_facet | Megumi Takasago Naoto Kunii Misako Komatsu Mariko Tada Mariko Tada Kenji Kirihara Takanori Uka Yohei Ishishita Seijiro Shimada Kiyoto Kasai Kiyoto Kasai Nobuhito Saito |
| author_sort | Megumi Takasago |
| collection | DOAJ |
| description | Auditory mismatch negativity (MMN) is an electrophysiological response to a deviation from regularity. This response is considered pivotal to understanding auditory processing, particularly in the pre-attentive phase. However, previous findings suggest that MMN is a product of N1 adaptation/enhancement, which reflects lower-order auditory processing. The separability of these two components remains unclear and is considered an important issue in the field of neuroscience. The aim of the present study was to spatiotemporally differentiate MMN from N1 adaptation using human electrocorticography (ECoG). Auditory evoked potentials under the classical oddball (OD) task as well as the many standards (MS) task were recorded in three patients with epilepsy whose lateral cortices were widely covered with high-density electrodes. Close observation identified an electrode at which N1 adaptation was temporally separated from MMN, whereas N1 adaptation was partially incorporated into MMN at other electrodes. Since N1 adaptation occurs in the N1 population, we spatially compared MMN with N1 obtained from the MS task instead of N1 adaptation. As a result, N1 was observed in a limited area around the Sylvian fissure adjacent to A1, whereas MMN was noted in wider areas, including the temporal, frontal, and parietal lobes. MMN was thus considered to be differentiated from N1 adaptation. The results suggest that MMN is not merely a product of the neural adaptation of N1 and instead represents higher-order processes in auditory deviance detection. These results will contribute to strengthening the foundation of future research in this field. |
| first_indexed | 2024-12-20T12:12:58Z |
| format | Article |
| id | doaj.art-e88b5a72e9b442699b2a4c68f9139625 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-20T12:12:58Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-e88b5a72e9b442699b2a4c68f91396252022-12-21T19:41:12ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-06-011110.3389/fpsyt.2020.00586552062Spatiotemporal Differentiation of MMN From N1 Adaptation: A Human ECoG StudyMegumi Takasago0Naoto Kunii1Misako Komatsu2Mariko Tada3Mariko Tada4Kenji Kirihara5Takanori Uka6Yohei Ishishita7Seijiro Shimada8Kiyoto Kasai9Kiyoto Kasai10Nobuhito Saito11Department of Neurosurgery, The University of Tokyo, Tokyo, JapanDepartment of Neurosurgery, The University of Tokyo, Tokyo, JapanLaboratory for Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science, Wako, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanThe International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Integrative Physiology, Graduate School of Medicine, University of Yamanashi, Yamanashi, JapanDepartment of Neurosurgery, Jichi Medical University, Shimotuke, JapanDepartment of Neurosurgery, The University of Tokyo, Tokyo, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanThe International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), Tokyo, JapanDepartment of Neurosurgery, The University of Tokyo, Tokyo, JapanAuditory mismatch negativity (MMN) is an electrophysiological response to a deviation from regularity. This response is considered pivotal to understanding auditory processing, particularly in the pre-attentive phase. However, previous findings suggest that MMN is a product of N1 adaptation/enhancement, which reflects lower-order auditory processing. The separability of these two components remains unclear and is considered an important issue in the field of neuroscience. The aim of the present study was to spatiotemporally differentiate MMN from N1 adaptation using human electrocorticography (ECoG). Auditory evoked potentials under the classical oddball (OD) task as well as the many standards (MS) task were recorded in three patients with epilepsy whose lateral cortices were widely covered with high-density electrodes. Close observation identified an electrode at which N1 adaptation was temporally separated from MMN, whereas N1 adaptation was partially incorporated into MMN at other electrodes. Since N1 adaptation occurs in the N1 population, we spatially compared MMN with N1 obtained from the MS task instead of N1 adaptation. As a result, N1 was observed in a limited area around the Sylvian fissure adjacent to A1, whereas MMN was noted in wider areas, including the temporal, frontal, and parietal lobes. MMN was thus considered to be differentiated from N1 adaptation. The results suggest that MMN is not merely a product of the neural adaptation of N1 and instead represents higher-order processes in auditory deviance detection. These results will contribute to strengthening the foundation of future research in this field.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00586/fullauditory mismatch negativity (auditory MMN)N1electrocorticography (ECoG)event-related potential (ERP)adaptationdeviance detection |
| spellingShingle | Megumi Takasago Naoto Kunii Misako Komatsu Mariko Tada Mariko Tada Kenji Kirihara Takanori Uka Yohei Ishishita Seijiro Shimada Kiyoto Kasai Kiyoto Kasai Nobuhito Saito Spatiotemporal Differentiation of MMN From N1 Adaptation: A Human ECoG Study Frontiers in Psychiatry auditory mismatch negativity (auditory MMN) N1 electrocorticography (ECoG) event-related potential (ERP) adaptation deviance detection |
| title | Spatiotemporal Differentiation of MMN From N1 Adaptation: A Human ECoG Study |
| title_full | Spatiotemporal Differentiation of MMN From N1 Adaptation: A Human ECoG Study |
| title_fullStr | Spatiotemporal Differentiation of MMN From N1 Adaptation: A Human ECoG Study |
| title_full_unstemmed | Spatiotemporal Differentiation of MMN From N1 Adaptation: A Human ECoG Study |
| title_short | Spatiotemporal Differentiation of MMN From N1 Adaptation: A Human ECoG Study |
| title_sort | spatiotemporal differentiation of mmn from n1 adaptation a human ecog study |
| topic | auditory mismatch negativity (auditory MMN) N1 electrocorticography (ECoG) event-related potential (ERP) adaptation deviance detection |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00586/full |
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