Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis
Abstract Background The role of air pollution in increasing susceptibility to respiratory tract infections in the cystic fibrosis (CF) population has not been well described. We recently demonstrated that chronic PM2.5 exposure is associated with an increased risk of initial Pseudomonas aeruginosa a...
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12890-017-0449-8 |
| _version_ | 1811263531497029632 |
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| author | Kevin J. Psoter Anneclaire J. De Roos Jon Wakefield Jonathan D. Mayer Margaret Rosenfeld |
| author_facet | Kevin J. Psoter Anneclaire J. De Roos Jon Wakefield Jonathan D. Mayer Margaret Rosenfeld |
| author_sort | Kevin J. Psoter |
| collection | DOAJ |
| description | Abstract Background The role of air pollution in increasing susceptibility to respiratory tract infections in the cystic fibrosis (CF) population has not been well described. We recently demonstrated that chronic PM2.5 exposure is associated with an increased risk of initial Pseudomonas aeruginosa acquisition in young children with CF. The purpose of this study was to determine whether PM2.5 exposure is a risk factor for acquisition of other respiratory pathogens in young children with CF. Methods We conducted a retrospective study of initial acquisition of methicillin susceptible and methicillin resistant Staphylococcus aureus (MSSA and MRSA), Stenotrophomonas maltophilia and Achromobacter xylosoxidans in U.S. children <6 years of age with CF using the CF Foundation Patient Registry, 2003–2009. Multivariable Weibull regression with interval-censored outcomes was used to evaluate the association of PM2.5 concentration in the year prior to birth and risk of acquisition of each organism. Results During follow-up 63%, 17%, 24%, and 5% of children acquired MSSA, MRSA, S. maltophilia, and A. xylosoxidans, respectively. A 10 μg/m3 increase in PM2.5 exposure was associated with a 68% increased risk of MRSA acquisition (Hazard Ratio: 1.68; 95% Confidence Interval: 1.24, 2.27). PM2.5 was not associated with acquisition of other respiratory pathogens. Conclusions Fine particulate matter is an independent risk factor for initial MRSA acquisition in young children with CF. These results support the increasing evidence that air pollution contributes to pulmonary morbidities in the CF community. |
| first_indexed | 2024-04-12T19:45:50Z |
| format | Article |
| id | doaj.art-e88c4b7bf81b4049ab85c9fec04adf12 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-12T19:45:50Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-e88c4b7bf81b4049ab85c9fec04adf122022-12-22T03:18:57ZengBMCBMC Pulmonary Medicine1471-24662017-07-011711910.1186/s12890-017-0449-8Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosisKevin J. Psoter0Anneclaire J. De Roos1Jon Wakefield2Jonathan D. Mayer3Margaret Rosenfeld4Department of Pediatrics, School of Medicine, The Johns Hopkins University Bayview Medical CenterDepartment of Environmental and Occupational Health, Drexel University School of Public HealthDepartments of Biostatistics and Statistics, University of WashingtonDepartments of Epidemiology, Geography, Global Health, Medicine (Allergy and Infectious Diseases), Family Medicine, and Health Services, University of WashingtonDivision of Pulmonary Medicine, University of Washington School of MedicineAbstract Background The role of air pollution in increasing susceptibility to respiratory tract infections in the cystic fibrosis (CF) population has not been well described. We recently demonstrated that chronic PM2.5 exposure is associated with an increased risk of initial Pseudomonas aeruginosa acquisition in young children with CF. The purpose of this study was to determine whether PM2.5 exposure is a risk factor for acquisition of other respiratory pathogens in young children with CF. Methods We conducted a retrospective study of initial acquisition of methicillin susceptible and methicillin resistant Staphylococcus aureus (MSSA and MRSA), Stenotrophomonas maltophilia and Achromobacter xylosoxidans in U.S. children <6 years of age with CF using the CF Foundation Patient Registry, 2003–2009. Multivariable Weibull regression with interval-censored outcomes was used to evaluate the association of PM2.5 concentration in the year prior to birth and risk of acquisition of each organism. Results During follow-up 63%, 17%, 24%, and 5% of children acquired MSSA, MRSA, S. maltophilia, and A. xylosoxidans, respectively. A 10 μg/m3 increase in PM2.5 exposure was associated with a 68% increased risk of MRSA acquisition (Hazard Ratio: 1.68; 95% Confidence Interval: 1.24, 2.27). PM2.5 was not associated with acquisition of other respiratory pathogens. Conclusions Fine particulate matter is an independent risk factor for initial MRSA acquisition in young children with CF. These results support the increasing evidence that air pollution contributes to pulmonary morbidities in the CF community.http://link.springer.com/article/10.1186/s12890-017-0449-8Cystic fibrosisStaphylococcus aureusMRSAStenotrophomonas maltophiliaAchromobacter xylosoxidansFine particulate matter |
| spellingShingle | Kevin J. Psoter Anneclaire J. De Roos Jon Wakefield Jonathan D. Mayer Margaret Rosenfeld Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis BMC Pulmonary Medicine Cystic fibrosis Staphylococcus aureus MRSA Stenotrophomonas maltophilia Achromobacter xylosoxidans Fine particulate matter |
| title | Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis |
| title_full | Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis |
| title_fullStr | Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis |
| title_full_unstemmed | Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis |
| title_short | Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis |
| title_sort | air pollution exposure is associated with mrsa acquisition in young u s children with cystic fibrosis |
| topic | Cystic fibrosis Staphylococcus aureus MRSA Stenotrophomonas maltophilia Achromobacter xylosoxidans Fine particulate matter |
| url | http://link.springer.com/article/10.1186/s12890-017-0449-8 |
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