Nicotine increases cerebellar activity during finger tapping.
Nicotine improves performance on several cognitive and sensorimotor tasks. The neuronal mechanisms associated with these changes in performance are, however, largely unknown. Functional magnetic resonance imaging (fMRI) was used to examine the effect of nicotine on neuronal response in nineteen heal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3866129?pdf=render |
| _version_ | 1818561769089531904 |
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| author | Korey P Wylie Jody Tanabe Laura F Martin Narin Wongngamnit Jason R Tregellas |
| author_facet | Korey P Wylie Jody Tanabe Laura F Martin Narin Wongngamnit Jason R Tregellas |
| author_sort | Korey P Wylie |
| collection | DOAJ |
| description | Nicotine improves performance on several cognitive and sensorimotor tasks. The neuronal mechanisms associated with these changes in performance are, however, largely unknown. Functional magnetic resonance imaging (fMRI) was used to examine the effect of nicotine on neuronal response in nineteen healthy subjects while they performed an auditory-paced finger tapping task. Subjects performed the task, after receiving either a nicotine patch or placebo treatment, in a single blind, crossover design. Compared to placebo, nicotine treatment increased response in the cerebellar vermis. Increased vermal activity, in the absence of changes in other task-related regions suggests specificity in nicotine's effects. |
| first_indexed | 2024-12-14T00:55:04Z |
| format | Article |
| id | doaj.art-e88fac74ba66446f946c87df7eb1938d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T00:55:04Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e88fac74ba66446f946c87df7eb1938d2022-12-21T23:23:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8458110.1371/journal.pone.0084581Nicotine increases cerebellar activity during finger tapping.Korey P WylieJody TanabeLaura F MartinNarin WongngamnitJason R TregellasNicotine improves performance on several cognitive and sensorimotor tasks. The neuronal mechanisms associated with these changes in performance are, however, largely unknown. Functional magnetic resonance imaging (fMRI) was used to examine the effect of nicotine on neuronal response in nineteen healthy subjects while they performed an auditory-paced finger tapping task. Subjects performed the task, after receiving either a nicotine patch or placebo treatment, in a single blind, crossover design. Compared to placebo, nicotine treatment increased response in the cerebellar vermis. Increased vermal activity, in the absence of changes in other task-related regions suggests specificity in nicotine's effects.http://europepmc.org/articles/PMC3866129?pdf=render |
| spellingShingle | Korey P Wylie Jody Tanabe Laura F Martin Narin Wongngamnit Jason R Tregellas Nicotine increases cerebellar activity during finger tapping. PLoS ONE |
| title | Nicotine increases cerebellar activity during finger tapping. |
| title_full | Nicotine increases cerebellar activity during finger tapping. |
| title_fullStr | Nicotine increases cerebellar activity during finger tapping. |
| title_full_unstemmed | Nicotine increases cerebellar activity during finger tapping. |
| title_short | Nicotine increases cerebellar activity during finger tapping. |
| title_sort | nicotine increases cerebellar activity during finger tapping |
| url | http://europepmc.org/articles/PMC3866129?pdf=render |
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