Inhibiting FAK–Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells

Inhibiting FAK–Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells

The nonreceptor tyrosine kinase FAK is a promising target for solid tumor treatment because it promotes invasion, tumor progression, and drug resistance when overexpressed. Investigating the role of FAK in human melanoma cells, we found that both in situ and metastatic melanoma cells strongly expres...

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Bibliographic Details
Main Authors: Antoine Mousson, Marlène Legrand, Tania Steffan, Romain Vauchelles, Philippe Carl, Jean-Pierre Gies, Maxime Lehmann, Guy Zuber, Jan De Mey, Denis Dujardin, Emilie Sick, Philippe Rondé
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
FAK
tyrosine kinase inhibitor
paxillin
invadopodia
migration
melanoma
Online Access:https://www.mdpi.com/2072-6694/13/8/1871

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