MiR-454-3p promotes apoptosis and autophagy of AML cells by targeting ZEB2 and regulating AKT/mTOR pathway

MiR-454-3p promotes apoptosis and autophagy of AML cells by targeting ZEB2 and regulating AKT/mTOR pathway

ABSTRACTBackground miR-454-3p is considered to have a crucial role in cancer progression, but the potential involvement in acute myeloid leukemia (AML) remains unclear.Methods Expression of miR-454-3p and ZEB2 mRNA and protein were quantified in AML cell lines. Cells were transfected with miR-454-3p...

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Bibliographic Details
Main Authors: Xiao Wang, Liang Zhong, Wenran Dan, Xuan Chu, Xu Luo, Chen Liu, Peng Wan, Yang Lu, Zhenyan Liu, Zhonghui Zhang, Beizhong Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Hematology
Subjects:
miR-454-3p
AML
ZEB2
apoptosis
autophagy
AKT/mTOR pathway
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2023.2223874

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