Immune response to influenza vaccination in children with cancer
The aim of this study was to evaluate the ability of influenza immunization to evoke a protective immune response among children with cancer. We evaluated 75 children with cancer who received influenza vaccination. Hemagglutination Inhibition Antibody titers were determined before and after vaccinat...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-09-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1470734 |
| _version_ | 1827809863357431808 |
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| author | Dimitrios Doganis Athanasia Kafasi Helen Dana Nikolaos Spanakis Margarita Baka Apostolos Pourtsidis Triantafyllia Sdogou Artemis Vintila Vaia Rafailidou Panagiota Chantzi Marina Servitzoglou Despina Bouhoutsou Maria Varvoutsi Helen Kosmidis Maria Tsolia |
| author_facet | Dimitrios Doganis Athanasia Kafasi Helen Dana Nikolaos Spanakis Margarita Baka Apostolos Pourtsidis Triantafyllia Sdogou Artemis Vintila Vaia Rafailidou Panagiota Chantzi Marina Servitzoglou Despina Bouhoutsou Maria Varvoutsi Helen Kosmidis Maria Tsolia |
| author_sort | Dimitrios Doganis |
| collection | DOAJ |
| description | The aim of this study was to evaluate the ability of influenza immunization to evoke a protective immune response among children with cancer. We evaluated 75 children with cancer who received influenza vaccination. Hemagglutination Inhibition Antibody titers were determined before and after vaccination. The protective rates after vaccination were 79% for H1N1, 75% for H3N2 and 59% for influenza B virus whereas the seroconversion rates were 54%, 44% and 43% respectively. The differences pre- and post-vaccination were significant regardless the method which was used: seroprotection changes, seroconversion and geometric mean titers analyses. Variables such as the pre-vaccination antibody titers, the time when the responses were measured after the vaccination, the age and the type of malignancy as well as the absolute lymphocyte count were found to be correlated with the immune response but the findings were different for each vaccine subunit. In conclusion, influenza vaccination provides protection in a remarkable proportion of pediatric cancer patients whereas this protection is more obvious against H1N1 and H3N2 compared to influenza B. The immune response after vaccination is significant and seems to be influenced by a variety of factors. |
| first_indexed | 2024-03-11T22:46:15Z |
| format | Article |
| id | doaj.art-e8967e4795ef4c79a061554ee9569e60 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:46:15Z |
| publishDate | 2018-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-e8967e4795ef4c79a061554ee9569e602023-09-22T08:38:21ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-09-011492310231710.1080/21645515.2018.14707341470734Immune response to influenza vaccination in children with cancerDimitrios Doganis0Athanasia Kafasi1Helen Dana2Nikolaos Spanakis3Margarita Baka4Apostolos Pourtsidis5Triantafyllia Sdogou6Artemis Vintila7Vaia Rafailidou8Panagiota Chantzi9Marina Servitzoglou10Despina Bouhoutsou11Maria Varvoutsi12Helen Kosmidis13Maria Tsolia14P & A Kyriakou Children's HospitalNational and Kapodistrian University of Athens (NKUA), School of MedicineP & A Kyriakou Children's HospitalNational and Kapodistrian University of Athens (NKUA), School of MedicineP & A Kyriakou Children's HospitalP & A Kyriakou Children's HospitalNational and Kapodistrian University of Athens (NKUA), School of Medicine, P. and A. Kyriakou Children's hospitalNational and Kapodistrian University of Athens (NKUA), School of Medicine, P. and A. Kyriakou Children's hospitalP & A Kyriakou Children's HospitalP & A Kyriakou Children's HospitalP & A Kyriakou Children's HospitalP & A Kyriakou Children's HospitalP & A Kyriakou Children's HospitalP & A Kyriakou Children's HospitalNational and Kapodistrian University of Athens (NKUA), School of Medicine, P. and A. Kyriakou Children's hospitalThe aim of this study was to evaluate the ability of influenza immunization to evoke a protective immune response among children with cancer. We evaluated 75 children with cancer who received influenza vaccination. Hemagglutination Inhibition Antibody titers were determined before and after vaccination. The protective rates after vaccination were 79% for H1N1, 75% for H3N2 and 59% for influenza B virus whereas the seroconversion rates were 54%, 44% and 43% respectively. The differences pre- and post-vaccination were significant regardless the method which was used: seroprotection changes, seroconversion and geometric mean titers analyses. Variables such as the pre-vaccination antibody titers, the time when the responses were measured after the vaccination, the age and the type of malignancy as well as the absolute lymphocyte count were found to be correlated with the immune response but the findings were different for each vaccine subunit. In conclusion, influenza vaccination provides protection in a remarkable proportion of pediatric cancer patients whereas this protection is more obvious against H1N1 and H3N2 compared to influenza B. The immune response after vaccination is significant and seems to be influenced by a variety of factors.http://dx.doi.org/10.1080/21645515.2018.1470734influenzacancerchildrenvaccinationimmune responseimmunogenicityinfluenzapediatrics |
| spellingShingle | Dimitrios Doganis Athanasia Kafasi Helen Dana Nikolaos Spanakis Margarita Baka Apostolos Pourtsidis Triantafyllia Sdogou Artemis Vintila Vaia Rafailidou Panagiota Chantzi Marina Servitzoglou Despina Bouhoutsou Maria Varvoutsi Helen Kosmidis Maria Tsolia Immune response to influenza vaccination in children with cancer Human Vaccines & Immunotherapeutics influenza cancer children vaccination immune response immunogenicity influenza pediatrics |
| title | Immune response to influenza vaccination in children with cancer |
| title_full | Immune response to influenza vaccination in children with cancer |
| title_fullStr | Immune response to influenza vaccination in children with cancer |
| title_full_unstemmed | Immune response to influenza vaccination in children with cancer |
| title_short | Immune response to influenza vaccination in children with cancer |
| title_sort | immune response to influenza vaccination in children with cancer |
| topic | influenza cancer children vaccination immune response immunogenicity influenza pediatrics |
| url | http://dx.doi.org/10.1080/21645515.2018.1470734 |
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