HISTOIMMUNOLOGICAL CHANGES IN THE URINARY SYSTEM OF WISTER ALBINO RAT RESULTED FROM Proteus mirabilis Infestations
Urine samples of human's mid-stream urinary tract were collected from patients (males and females)who suffered from signs of urinary tract problems . These specified bacteria were isolated and classified according to species .Bacteriological results indicated the existence of P.mirabilis, which...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of Anbar
2012-06-01
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| Series: | مجلة جامعة الانبار للعلوم الصرفة |
| Subjects: | |
| Online Access: | https://juaps.uoanbar.edu.iq/article_15295_4fa1efa077a41ef086e3a77ffc0ad528.pdf |
| Summary: | Urine samples of human's mid-stream urinary tract were collected from patients (males and females)who suffered from signs of urinary tract problems . These specified bacteria were isolated and classified according to species .Bacteriological results indicated the existence of P.mirabilis, which was the most familiar kind to cause these infections compared to other bacteria . A dose of 9.0 × 109 alive P.mirabilis bacterial cells was injected after being killed on bases of a limited period of time intraperitonially in each laboratory rat ,signs of infections were noticed and later extra histoimmunopathological changes were studied in accordance with their sickness stages. Results Showed the followings: Bacterial infections were persistent and their severity was varied between acute and chronic infections for all the period of the experiment .These conditions were positive for all the urinary tract components, urethras ,urinary bladder and urethra. The strength of histoimmunopathological changes was varied among rats of the same group for all the period of the experiment ,but in general these changes varied from simple to moderate specially in the first week of inoculation .However ,animals did have symptoms such as hyperemia and edema while others suffered from necrosis , staffing of medulla , hyaline casts and inflammatory edema . Inflammation severity was increased after the first week and animals suffered from a wide destruction in their kidney tissue because of inflammable edema which experienced neutrophils penetration in the kidney tissues and the collective tubules ; as a result, R.B.C `s were presented in their urine . Moreover, in the second week their inflammatory conditions were variably extended to chronic inflammation in the bladder through the urethras and then to urethra . Also, swelling of the mucous membrane of the bladder and urethra. Rats may have inflammable edema and chancre with severe edema in the inflamed cells |
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| ISSN: | 1991-8941 2706-6703 |