Saffron and its active ingredients against human disorders: A literature review on existing clinical evidence
Saffron, the stigmas of Crocus sativus L., has been mentioned extensively in the traditional reference texts as a herbal medicine. Many clinical trials have been conducted on this valuable herbal substance and its main constituents following numerous cellular and animal assessments. In the present r...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2022-08-01
|
| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | https://ijbms.mums.ac.ir/article_20685_f0ed7d7e5c231be3bffda2cc28c1f6b7.pdf |
| _version_ | 1811247916800540672 |
|---|---|
| author | Seyedeh Farzaneh Omidkhoda Hossein Hosseinzadeh |
| author_facet | Seyedeh Farzaneh Omidkhoda Hossein Hosseinzadeh |
| author_sort | Seyedeh Farzaneh Omidkhoda |
| collection | DOAJ |
| description | Saffron, the stigmas of Crocus sativus L., has been mentioned extensively in the traditional reference texts as a herbal medicine. Many clinical trials have been conducted on this valuable herbal substance and its main constituents following numerous cellular and animal assessments. In the present review, we have collected almost all of these clinical studies to clarify how much knowledge has clinically been achieved in this field so far and which scientific gaps are needed to be filled by more studies. A comprehensive literature review was conducted through a two-round search. First, we performed a general search for identifying the human disorders against which saffron was studied. Then, we searched specifically for the combination of saffron keywords and each disease name. Scientific databases including Scopus, PubMed, and Web of science were used for this search. Studies were collected through electronic databases from their inception up to August 2021. The largest number of these clinical studies represent the investigations into saffron efficacy in different neurological and mental disorders, particularly depression. This substance has clinically revealed significant protective effects against various types of depression, age-related macular degeneration, and allergic asthma. In some cases, such as sexual dysfunction, cognitive and metabolic disorder, the effects of saffron are still clinically open to dispute, or there are limited data on its positive influences. Overall, saffron and its constituents have promising effects on human disorders; however, it needs more clinical evidence or meta-analyses to be confirmed. |
| first_indexed | 2024-04-12T15:17:54Z |
| format | Article |
| id | doaj.art-e89762513bde498e8cf7c7ef32ed717f |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-12T15:17:54Z |
| publishDate | 2022-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-e89762513bde498e8cf7c7ef32ed717f2022-12-22T03:27:34ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742022-08-0125891393310.22038/ijbms.2022.63378.1398520685Saffron and its active ingredients against human disorders: A literature review on existing clinical evidenceSeyedeh Farzaneh Omidkhoda0Hossein Hosseinzadeh1Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranSaffron, the stigmas of Crocus sativus L., has been mentioned extensively in the traditional reference texts as a herbal medicine. Many clinical trials have been conducted on this valuable herbal substance and its main constituents following numerous cellular and animal assessments. In the present review, we have collected almost all of these clinical studies to clarify how much knowledge has clinically been achieved in this field so far and which scientific gaps are needed to be filled by more studies. A comprehensive literature review was conducted through a two-round search. First, we performed a general search for identifying the human disorders against which saffron was studied. Then, we searched specifically for the combination of saffron keywords and each disease name. Scientific databases including Scopus, PubMed, and Web of science were used for this search. Studies were collected through electronic databases from their inception up to August 2021. The largest number of these clinical studies represent the investigations into saffron efficacy in different neurological and mental disorders, particularly depression. This substance has clinically revealed significant protective effects against various types of depression, age-related macular degeneration, and allergic asthma. In some cases, such as sexual dysfunction, cognitive and metabolic disorder, the effects of saffron are still clinically open to dispute, or there are limited data on its positive influences. Overall, saffron and its constituents have promising effects on human disorders; however, it needs more clinical evidence or meta-analyses to be confirmed.https://ijbms.mums.ac.ir/article_20685_f0ed7d7e5c231be3bffda2cc28c1f6b7.pdfclinical trialcrocindiseasedisordersaffrontherapy |
| spellingShingle | Seyedeh Farzaneh Omidkhoda Hossein Hosseinzadeh Saffron and its active ingredients against human disorders: A literature review on existing clinical evidence Iranian Journal of Basic Medical Sciences clinical trial crocin disease disorder saffron therapy |
| title | Saffron and its active ingredients against human disorders: A literature review on existing clinical evidence |
| title_full | Saffron and its active ingredients against human disorders: A literature review on existing clinical evidence |
| title_fullStr | Saffron and its active ingredients against human disorders: A literature review on existing clinical evidence |
| title_full_unstemmed | Saffron and its active ingredients against human disorders: A literature review on existing clinical evidence |
| title_short | Saffron and its active ingredients against human disorders: A literature review on existing clinical evidence |
| title_sort | saffron and its active ingredients against human disorders a literature review on existing clinical evidence |
| topic | clinical trial crocin disease disorder saffron therapy |
| url | https://ijbms.mums.ac.ir/article_20685_f0ed7d7e5c231be3bffda2cc28c1f6b7.pdf |
| work_keys_str_mv | AT seyedehfarzanehomidkhoda saffronanditsactiveingredientsagainsthumandisordersaliteraturereviewonexistingclinicalevidence AT hosseinhosseinzadeh saffronanditsactiveingredientsagainsthumandisordersaliteraturereviewonexistingclinicalevidence |