Low plasma renin activity is associated with “Apparently” idiopathic atrial fibrillation
Background: Previous studies have reported the direct or indirect relationship between the renin-angiotensin-aldosterone system (RAAS) and atrial fibrillation (AF). However, in patients with “apparently” idiopathic AF without possible external influence, whether RAAS is dysregulated at an early stag...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906723001173 |
| _version_ | 1797398600458698752 |
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| author | Youmei Shen Guodong Ma Min Sun Mingfang Li Minglong Chen |
| author_facet | Youmei Shen Guodong Ma Min Sun Mingfang Li Minglong Chen |
| author_sort | Youmei Shen |
| collection | DOAJ |
| description | Background: Previous studies have reported the direct or indirect relationship between the renin-angiotensin-aldosterone system (RAAS) and atrial fibrillation (AF). However, in patients with “apparently” idiopathic AF without possible external influence, whether RAAS is dysregulated at an early stage of AF and its relationship with the recurrence of AF after ablation have not been studied. Methods: This single-center, prospective, case-control study included apparently healthy individuals with AF (the case group) or paroxysmal supraventricular tachycardia (PSVT, the control group) referred for catheter ablation at the same period. The primary outcome was RAAS activation in these two groups. The secondary outcome was the 1-year recurrence of AF after ablation. Results: This study included 51 “apparently” idiopathic AF and 91 patients with PSVT. A greater proportion of patients in the case group had plasma renin activity (PRA) levels < 1 ng/ml/h compared to the control group (25.5 % vs. 7.7 %, P = 0.003). PRA < 1 ng/ml/h was the only factor found to be associated with the diagnose of AF in both the univariate model (odds ratio [OR] 4.11, 95 % confidence interval [CI] 1.52–11.11, P = 0.005) and the model adjusted for age and sex (OR 3.98, 95 % CI 1.20–13.25, P = 0.024). A similar pattern was seen with paroxysmal AF. No significant difference in the components of RAAS was observed between 11 patients with the recurrence of AF and 40 without the recurrence at the 1-year follow-up. Conclusions: This observational study revealed an association between low renin activity and the diagnosis of “apparently” idiopathic AF, particularly paroxysmal AF. |
| first_indexed | 2024-03-09T01:27:53Z |
| format | Article |
| id | doaj.art-e898fb5785fb47df9088a022f3b897bf |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-03-09T01:27:53Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-e898fb5785fb47df9088a022f3b897bf2023-12-10T06:16:28ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672023-12-0149101286Low plasma renin activity is associated with “Apparently” idiopathic atrial fibrillationYoumei Shen0Guodong Ma1Min Sun2Mingfang Li3Minglong Chen4Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, ChinaDivision of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, ChinaDivision of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, China; Corresponding authors.Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, China; Corresponding authors.Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, ChinaBackground: Previous studies have reported the direct or indirect relationship between the renin-angiotensin-aldosterone system (RAAS) and atrial fibrillation (AF). However, in patients with “apparently” idiopathic AF without possible external influence, whether RAAS is dysregulated at an early stage of AF and its relationship with the recurrence of AF after ablation have not been studied. Methods: This single-center, prospective, case-control study included apparently healthy individuals with AF (the case group) or paroxysmal supraventricular tachycardia (PSVT, the control group) referred for catheter ablation at the same period. The primary outcome was RAAS activation in these two groups. The secondary outcome was the 1-year recurrence of AF after ablation. Results: This study included 51 “apparently” idiopathic AF and 91 patients with PSVT. A greater proportion of patients in the case group had plasma renin activity (PRA) levels < 1 ng/ml/h compared to the control group (25.5 % vs. 7.7 %, P = 0.003). PRA < 1 ng/ml/h was the only factor found to be associated with the diagnose of AF in both the univariate model (odds ratio [OR] 4.11, 95 % confidence interval [CI] 1.52–11.11, P = 0.005) and the model adjusted for age and sex (OR 3.98, 95 % CI 1.20–13.25, P = 0.024). A similar pattern was seen with paroxysmal AF. No significant difference in the components of RAAS was observed between 11 patients with the recurrence of AF and 40 without the recurrence at the 1-year follow-up. Conclusions: This observational study revealed an association between low renin activity and the diagnosis of “apparently” idiopathic AF, particularly paroxysmal AF.http://www.sciencedirect.com/science/article/pii/S2352906723001173Atrial fibrillationThe renin-angiotensin-aldosterone systemAldosterone-renin rationPlasma renin activity |
| spellingShingle | Youmei Shen Guodong Ma Min Sun Mingfang Li Minglong Chen Low plasma renin activity is associated with “Apparently” idiopathic atrial fibrillation International Journal of Cardiology: Heart & Vasculature Atrial fibrillation The renin-angiotensin-aldosterone system Aldosterone-renin ration Plasma renin activity |
| title | Low plasma renin activity is associated with “Apparently” idiopathic atrial fibrillation |
| title_full | Low plasma renin activity is associated with “Apparently” idiopathic atrial fibrillation |
| title_fullStr | Low plasma renin activity is associated with “Apparently” idiopathic atrial fibrillation |
| title_full_unstemmed | Low plasma renin activity is associated with “Apparently” idiopathic atrial fibrillation |
| title_short | Low plasma renin activity is associated with “Apparently” idiopathic atrial fibrillation |
| title_sort | low plasma renin activity is associated with apparently idiopathic atrial fibrillation |
| topic | Atrial fibrillation The renin-angiotensin-aldosterone system Aldosterone-renin ration Plasma renin activity |
| url | http://www.sciencedirect.com/science/article/pii/S2352906723001173 |
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