Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment
Abstract Magnetic heat-based brain stimulation of specific lesions could promote the restoration of impaired motor function caused by chronic stroke. We delivered localized stimulation by nanoparticle-mediated heat generation within the targeted brain area via focused magnetic stimulation. The middl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-31979-w |
| _version_ | 1797853885992271872 |
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| author | Hohyeon Kim Jihye Kim Jahae Kim Seungjun Oh Kangho Choi Jungwon Yoon |
| author_facet | Hohyeon Kim Jihye Kim Jahae Kim Seungjun Oh Kangho Choi Jungwon Yoon |
| author_sort | Hohyeon Kim |
| collection | DOAJ |
| description | Abstract Magnetic heat-based brain stimulation of specific lesions could promote the restoration of impaired motor function caused by chronic stroke. We delivered localized stimulation by nanoparticle-mediated heat generation within the targeted brain area via focused magnetic stimulation. The middle cerebral artery occlusion model was prepared, and functional recovery in the chronic-phase stroke rat model was demonstrated by the therapeutic application of focused magnetic stimulation. We observed a transient increase in blood–brain barrier permeability at the target site of < 4 mm and metabolic brain activation at the target lesion. After focused magnetic stimulation, the rotarod score increased by 390 ± 28% (p < 0.05) compared to the control group. Standardized uptake value in the focused magnetic stimulation group increased by 2063 ± 748% (p < 0.01) compared to the control group. Moreover, an increase by 24 ± 5% (p < 0.05) was observed in the sham group as well. Our results show that non-invasive focused magnetic stimulation can safely modulate BBB permeability and enhance neural activation for chronic-phase stroke treatment in the targeted deep brain area. |
| first_indexed | 2024-04-09T19:56:59Z |
| format | Article |
| id | doaj.art-e89e62b0186741e084c76ec4b3a60004 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T19:56:59Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e89e62b0186741e084c76ec4b3a600042023-04-03T05:24:56ZengNature PortfolioScientific Reports2045-23222023-03-0113111510.1038/s41598-023-31979-wMagnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatmentHohyeon Kim0Jihye Kim1Jahae Kim2Seungjun Oh3Kangho Choi4Jungwon Yoon5School of Integrated Technology, Gwangju Institute of Science and TechnologyDepartment of Neurology, Chonnam National University Hospital and Medical SchoolDepartment of Nuclear Medicines, Chonnam National University Hospital and Medical SchoolSchool of Integrated Technology, Gwangju Institute of Science and TechnologyDepartment of Neurology, Chonnam National University Hospital and Medical SchoolSchool of Integrated Technology, Gwangju Institute of Science and TechnologyAbstract Magnetic heat-based brain stimulation of specific lesions could promote the restoration of impaired motor function caused by chronic stroke. We delivered localized stimulation by nanoparticle-mediated heat generation within the targeted brain area via focused magnetic stimulation. The middle cerebral artery occlusion model was prepared, and functional recovery in the chronic-phase stroke rat model was demonstrated by the therapeutic application of focused magnetic stimulation. We observed a transient increase in blood–brain barrier permeability at the target site of < 4 mm and metabolic brain activation at the target lesion. After focused magnetic stimulation, the rotarod score increased by 390 ± 28% (p < 0.05) compared to the control group. Standardized uptake value in the focused magnetic stimulation group increased by 2063 ± 748% (p < 0.01) compared to the control group. Moreover, an increase by 24 ± 5% (p < 0.05) was observed in the sham group as well. Our results show that non-invasive focused magnetic stimulation can safely modulate BBB permeability and enhance neural activation for chronic-phase stroke treatment in the targeted deep brain area.https://doi.org/10.1038/s41598-023-31979-w |
| spellingShingle | Hohyeon Kim Jihye Kim Jahae Kim Seungjun Oh Kangho Choi Jungwon Yoon Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment Scientific Reports |
| title | Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment |
| title_full | Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment |
| title_fullStr | Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment |
| title_full_unstemmed | Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment |
| title_short | Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment |
| title_sort | magnetothermal based non invasive focused magnetic stimulation for functional recovery in chronic stroke treatment |
| url | https://doi.org/10.1038/s41598-023-31979-w |
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