Effects of Ketamine, Fentanyl and Paracetamol on Pain Intensity and Hemodynamic Parameters after Deep Vitrectomy
Background & objectives: The aim of this study was to evaluate the effects of preventive administration of ketamine, fentanyl and paracetamol on pain intensity and hemodynamic parameters after deep vitrectomy. Methods: In this clinical trial, 80 candidates of deep vitrectomy surgery were randoml...
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| Format: | Article |
| Language: | fas |
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Ardabil University of Medical Sciences
2021-03-01
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| Series: | Journal of Ardabil University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jarums.arums.ac.ir/article-1-2049-en.html |
| _version_ | 1818017495795105792 |
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| author | Hamid reza Shetabi Dariush Moradi farsani Mohammad Razani |
| author_facet | Hamid reza Shetabi Dariush Moradi farsani Mohammad Razani |
| author_sort | Hamid reza Shetabi |
| collection | DOAJ |
| description | Background & objectives: The aim of this study was to evaluate the effects of preventive administration of ketamine, fentanyl and paracetamol on pain intensity and hemodynamic parameters after deep vitrectomy.
Methods: In this clinical trial, 80 candidates of deep vitrectomy surgery were randomly assigned into 4 groups (1-4) and received 0.5 mg / kg ketamine, 2 μg / kg fentanyl, 10 mg/kg of paracetamol and equivolume of normal saline respectively intravenous infusion during the last 15 minutes of surgery. Pain intensity and hemodynamic parameters were recorded and analyzed.
Results: Pain intensity was significantly higher in placebo group during the first 4 hours after operation (p<0.01), but no significant differences were observed between the study groups at 8 and 24 hours after operation in this regard. There were no significant differences between the three intervention groups in terms of pain intensity during the study. Also there were no significant differences between the 4 study groups regarding to hemodynamic parameters.
Conclusion: The use of each of the three intervention drugs significantly reduced the pain intensity compared to the control group without any hemodynamic derangement. |
| first_indexed | 2024-04-14T07:27:50Z |
| format | Article |
| id | doaj.art-e89e82a906b54cc0a24c2721e20d01f8 |
| institution | Directory Open Access Journal |
| issn | 2228-7280 2228-7299 |
| language | fas |
| last_indexed | 2024-04-14T07:27:50Z |
| publishDate | 2021-03-01 |
| publisher | Ardabil University of Medical Sciences |
| record_format | Article |
| series | Journal of Ardabil University of Medical Sciences |
| spelling | doaj.art-e89e82a906b54cc0a24c2721e20d01f82022-12-22T02:05:58ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992021-03-0121190101Effects of Ketamine, Fentanyl and Paracetamol on Pain Intensity and Hemodynamic Parameters after Deep VitrectomyHamid reza Shetabi0Dariush Moradi farsani1Mohammad Razani2 Department of anesthesia, school of medicine, Isfahan University of medical sciences, Isfahan, Iran. Department of anesthesia, school of medicine, Isfahan University of medical sciences, Isfahan, Iran. Department of anesthesia, school of medicine, Isfahan University of medical sciences, Isfahan, Iran. Background & objectives: The aim of this study was to evaluate the effects of preventive administration of ketamine, fentanyl and paracetamol on pain intensity and hemodynamic parameters after deep vitrectomy. Methods: In this clinical trial, 80 candidates of deep vitrectomy surgery were randomly assigned into 4 groups (1-4) and received 0.5 mg / kg ketamine, 2 μg / kg fentanyl, 10 mg/kg of paracetamol and equivolume of normal saline respectively intravenous infusion during the last 15 minutes of surgery. Pain intensity and hemodynamic parameters were recorded and analyzed. Results: Pain intensity was significantly higher in placebo group during the first 4 hours after operation (p<0.01), but no significant differences were observed between the study groups at 8 and 24 hours after operation in this regard. There were no significant differences between the three intervention groups in terms of pain intensity during the study. Also there were no significant differences between the 4 study groups regarding to hemodynamic parameters. Conclusion: The use of each of the three intervention drugs significantly reduced the pain intensity compared to the control group without any hemodynamic derangement.http://jarums.arums.ac.ir/article-1-2049-en.htmldeep vitrectomyfentanylketaminepain intensityparacetamol |
| spellingShingle | Hamid reza Shetabi Dariush Moradi farsani Mohammad Razani Effects of Ketamine, Fentanyl and Paracetamol on Pain Intensity and Hemodynamic Parameters after Deep Vitrectomy Journal of Ardabil University of Medical Sciences deep vitrectomy fentanyl ketamine pain intensity paracetamol |
| title | Effects of Ketamine, Fentanyl and Paracetamol on Pain Intensity and Hemodynamic Parameters after Deep Vitrectomy |
| title_full | Effects of Ketamine, Fentanyl and Paracetamol on Pain Intensity and Hemodynamic Parameters after Deep Vitrectomy |
| title_fullStr | Effects of Ketamine, Fentanyl and Paracetamol on Pain Intensity and Hemodynamic Parameters after Deep Vitrectomy |
| title_full_unstemmed | Effects of Ketamine, Fentanyl and Paracetamol on Pain Intensity and Hemodynamic Parameters after Deep Vitrectomy |
| title_short | Effects of Ketamine, Fentanyl and Paracetamol on Pain Intensity and Hemodynamic Parameters after Deep Vitrectomy |
| title_sort | effects of ketamine fentanyl and paracetamol on pain intensity and hemodynamic parameters after deep vitrectomy |
| topic | deep vitrectomy fentanyl ketamine pain intensity paracetamol |
| url | http://jarums.arums.ac.ir/article-1-2049-en.html |
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