Long-Term Prognosis of Patients with Polypoidal Choroidal Vasculopathy Treated with Photodynamic Therapy
We evaluated the long-term prognosis of the eyes of patients with polypoidal choroidal vasculopathy (PCV) treated with photodynamic therapy (PDT). In total, 60 eyes of 57 patients diagnosed with PCV and treated with PDT were reviewed retrospectively in real-world settings. The best-corrected visual...
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/14/4707 |
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| author | Yukinori Sakaeda Aki Kato Soichiro Kuwayama Shuichiro Hirahara Norihiro Suzuki Yuichiro Ogura Yoko Nakazawa Tsutomu Yasukawa |
| author_facet | Yukinori Sakaeda Aki Kato Soichiro Kuwayama Shuichiro Hirahara Norihiro Suzuki Yuichiro Ogura Yoko Nakazawa Tsutomu Yasukawa |
| author_sort | Yukinori Sakaeda |
| collection | DOAJ |
| description | We evaluated the long-term prognosis of the eyes of patients with polypoidal choroidal vasculopathy (PCV) treated with photodynamic therapy (PDT). In total, 60 eyes of 57 patients diagnosed with PCV and treated with PDT were reviewed retrospectively in real-world settings. The best-corrected visual acuity (BCVA), central retinal thickness (CRT), anatomical findings (vision-threatening findings), and treatment history were assessed. In total, 38 eyes underwent PDT as the initial treatment (initial PDT group) and 22 eyes underwent PDT as a rescue treatment (rescue PDT group). In the initial PDT group, 11 eyes (29%) did not require additional therapy throughout the observation period and maintained good BCVA. A total of 27 eyes (71%) underwent additional treatments and the mean BCVA was only stabilized for 2 years; thereafter, decreased vision occurred even with additional treatments. In the rescue PDT group, 22 eyes (95%) required additional treatment. Hard exudate, serous pigment epithelial detachment, and the total vision-threatening score were related to worse BCVA. Initial PDT may be effective in about 30% of cases with preservation of good vision and no need for additional treatment. However, patients with received rescue PDT needed additional treatment in most cases and the vision decreased in many cases. |
| first_indexed | 2024-03-11T00:58:11Z |
| format | Article |
| id | doaj.art-e8a32fabc0484d9d8830c96610b69c90 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:58:11Z |
| publishDate | 2023-07-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-e8a32fabc0484d9d8830c96610b69c902023-11-18T19:52:49ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011214470710.3390/jcm12144707Long-Term Prognosis of Patients with Polypoidal Choroidal Vasculopathy Treated with Photodynamic TherapyYukinori Sakaeda0Aki Kato1Soichiro Kuwayama2Shuichiro Hirahara3Norihiro Suzuki4Yuichiro Ogura5Yoko Nakazawa6Tsutomu Yasukawa7Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JapanDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JapanDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JapanDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JapanDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JapanDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JapanDepartment of Ophthalmology, Nagoya City University, West Medical Center, 1-1-1 Hirate-cho, Kita-ku, Nagoya 462-8508, JapanDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JapanWe evaluated the long-term prognosis of the eyes of patients with polypoidal choroidal vasculopathy (PCV) treated with photodynamic therapy (PDT). In total, 60 eyes of 57 patients diagnosed with PCV and treated with PDT were reviewed retrospectively in real-world settings. The best-corrected visual acuity (BCVA), central retinal thickness (CRT), anatomical findings (vision-threatening findings), and treatment history were assessed. In total, 38 eyes underwent PDT as the initial treatment (initial PDT group) and 22 eyes underwent PDT as a rescue treatment (rescue PDT group). In the initial PDT group, 11 eyes (29%) did not require additional therapy throughout the observation period and maintained good BCVA. A total of 27 eyes (71%) underwent additional treatments and the mean BCVA was only stabilized for 2 years; thereafter, decreased vision occurred even with additional treatments. In the rescue PDT group, 22 eyes (95%) required additional treatment. Hard exudate, serous pigment epithelial detachment, and the total vision-threatening score were related to worse BCVA. Initial PDT may be effective in about 30% of cases with preservation of good vision and no need for additional treatment. However, patients with received rescue PDT needed additional treatment in most cases and the vision decreased in many cases.https://www.mdpi.com/2077-0383/12/14/4707age-related macular degenerationanti-vascular endothelial growth factor therapyphotodynamic therapypolypoidal choroidal vasculopathy |
| spellingShingle | Yukinori Sakaeda Aki Kato Soichiro Kuwayama Shuichiro Hirahara Norihiro Suzuki Yuichiro Ogura Yoko Nakazawa Tsutomu Yasukawa Long-Term Prognosis of Patients with Polypoidal Choroidal Vasculopathy Treated with Photodynamic Therapy Journal of Clinical Medicine age-related macular degeneration anti-vascular endothelial growth factor therapy photodynamic therapy polypoidal choroidal vasculopathy |
| title | Long-Term Prognosis of Patients with Polypoidal Choroidal Vasculopathy Treated with Photodynamic Therapy |
| title_full | Long-Term Prognosis of Patients with Polypoidal Choroidal Vasculopathy Treated with Photodynamic Therapy |
| title_fullStr | Long-Term Prognosis of Patients with Polypoidal Choroidal Vasculopathy Treated with Photodynamic Therapy |
| title_full_unstemmed | Long-Term Prognosis of Patients with Polypoidal Choroidal Vasculopathy Treated with Photodynamic Therapy |
| title_short | Long-Term Prognosis of Patients with Polypoidal Choroidal Vasculopathy Treated with Photodynamic Therapy |
| title_sort | long term prognosis of patients with polypoidal choroidal vasculopathy treated with photodynamic therapy |
| topic | age-related macular degeneration anti-vascular endothelial growth factor therapy photodynamic therapy polypoidal choroidal vasculopathy |
| url | https://www.mdpi.com/2077-0383/12/14/4707 |
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