Features of manifestation and progression for critical lower limb ischemia in subjects with abdominal aortic calcification: a pilot study
<p><strong>Aim.</strong> The study was designed to assess the specific features of manifestation and progression for critical low limb ischemia in patients with abdominal aortic calcification. <br /><strong>Methods.</strong> The total of 151 patients with low limb...
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| Format: | Article |
| Language: | English |
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Meshalkin National Medical Research Center
2017-11-01
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| Series: | Патология кровообращения и кардиохирургия |
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| Online Access: | http://journalmeshalkin.ru/index.php/heartjournal/article/view/442 |
| _version_ | 1797725844840382464 |
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| author | V. A. Zelinskiy M. V. Melynikov |
| author_facet | V. A. Zelinskiy M. V. Melynikov |
| author_sort | V. A. Zelinskiy |
| collection | DOAJ |
| description | <p><strong>Aim.</strong> The study was designed to assess the specific features of manifestation and progression for critical low limb ischemia in patients with abdominal aortic calcification. <br /><strong>Methods.</strong> The total of 151 patients with low limb critical ischemia due to peripheral arterial disease were enrolled to the study cohort: 79 patients (study group) with abdominal aortic calcification and 72 patients (control group) without any signs of abdominal aortic wall calcification. Abdominal aortic calcification was detected by CT-imaging. The patients with diabetes mellitus and with chronic renal insufficiency were excluded from the study cohort. <br /><strong>Results.</strong> Critical lower limb ischemia in subjects with abdominal aortic calcification manifested itself in the following features: predominant localization of lesions in the aorto-iliac position (68.4% vs. 33.3% in patients without abdominal aortic calcification; р<0.05), rapid progression of lower limb ischemia (its prevalence in the study group was 77.7% vs. 37.3% in the control group; р<0.01), expressed hypercoagulation combined with a decrease in the level of natural anticoagulants concentration (mean activity of antithrombin III in individuals with abdominal aortic calcification was 56.5±10.4% vs. 98.7±16.4% in patients without abdominal aortic calcification; р<0.001). <br /><strong>Conclusion.</strong> The study findings have shown that critical lower limb ischemia in subjects with abdominal aortic calcification has specific futures of manifestation and clinical course that need to be considered when choosing the best treatment strategy.</p><p>Received 24 April 2017. Revised 7 June 2017. Accepted 19 June 2017.</p><p><strong>Funding:</strong> The study did not have sponsorship.</p><p><strong>Conflict of interest:</strong> The authors declare no conflict of interest.</p> |
| first_indexed | 2024-03-12T10:37:04Z |
| format | Article |
| id | doaj.art-e8a51c22c47c4074a1705b8e763db318 |
| institution | Directory Open Access Journal |
| issn | 1681-3472 2500-3119 |
| language | English |
| last_indexed | 2024-03-12T10:37:04Z |
| publishDate | 2017-11-01 |
| publisher | Meshalkin National Medical Research Center |
| record_format | Article |
| series | Патология кровообращения и кардиохирургия |
| spelling | doaj.art-e8a51c22c47c4074a1705b8e763db3182023-09-02T08:37:09ZengMeshalkin National Medical Research CenterПатология кровообращения и кардиохирургия1681-34722500-31192017-11-01213586410.21688/1681-3472-2017-3-58-641120Features of manifestation and progression for critical lower limb ischemia in subjects with abdominal aortic calcification: a pilot studyV. A. Zelinskiy0M. V. Melynikov1ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова», Министерство здравоохранения Российской Федерации, Санкт-Петербург, Российская ФедерацияФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова», Министерство здравоохранения Российской Федерации, Санкт-Петербург, Российская Федерация<p><strong>Aim.</strong> The study was designed to assess the specific features of manifestation and progression for critical low limb ischemia in patients with abdominal aortic calcification. <br /><strong>Methods.</strong> The total of 151 patients with low limb critical ischemia due to peripheral arterial disease were enrolled to the study cohort: 79 patients (study group) with abdominal aortic calcification and 72 patients (control group) without any signs of abdominal aortic wall calcification. Abdominal aortic calcification was detected by CT-imaging. The patients with diabetes mellitus and with chronic renal insufficiency were excluded from the study cohort. <br /><strong>Results.</strong> Critical lower limb ischemia in subjects with abdominal aortic calcification manifested itself in the following features: predominant localization of lesions in the aorto-iliac position (68.4% vs. 33.3% in patients without abdominal aortic calcification; р<0.05), rapid progression of lower limb ischemia (its prevalence in the study group was 77.7% vs. 37.3% in the control group; р<0.01), expressed hypercoagulation combined with a decrease in the level of natural anticoagulants concentration (mean activity of antithrombin III in individuals with abdominal aortic calcification was 56.5±10.4% vs. 98.7±16.4% in patients without abdominal aortic calcification; р<0.001). <br /><strong>Conclusion.</strong> The study findings have shown that critical lower limb ischemia in subjects with abdominal aortic calcification has specific futures of manifestation and clinical course that need to be considered when choosing the best treatment strategy.</p><p>Received 24 April 2017. Revised 7 June 2017. Accepted 19 June 2017.</p><p><strong>Funding:</strong> The study did not have sponsorship.</p><p><strong>Conflict of interest:</strong> The authors declare no conflict of interest.</p>http://journalmeshalkin.ru/index.php/heartjournal/article/view/442периферический атеросклерозкальциноз брюшной аортыкритическая ишемия нижних конечностейразрыв атеросклеротической бляшки |
| spellingShingle | V. A. Zelinskiy M. V. Melynikov Features of manifestation and progression for critical lower limb ischemia in subjects with abdominal aortic calcification: a pilot study Патология кровообращения и кардиохирургия периферический атеросклероз кальциноз брюшной аорты критическая ишемия нижних конечностей разрыв атеросклеротической бляшки |
| title | Features of manifestation and progression for critical lower limb ischemia in subjects with abdominal aortic calcification: a pilot study |
| title_full | Features of manifestation and progression for critical lower limb ischemia in subjects with abdominal aortic calcification: a pilot study |
| title_fullStr | Features of manifestation and progression for critical lower limb ischemia in subjects with abdominal aortic calcification: a pilot study |
| title_full_unstemmed | Features of manifestation and progression for critical lower limb ischemia in subjects with abdominal aortic calcification: a pilot study |
| title_short | Features of manifestation and progression for critical lower limb ischemia in subjects with abdominal aortic calcification: a pilot study |
| title_sort | features of manifestation and progression for critical lower limb ischemia in subjects with abdominal aortic calcification a pilot study |
| topic | периферический атеросклероз кальциноз брюшной аорты критическая ишемия нижних конечностей разрыв атеросклеротической бляшки |
| url | http://journalmeshalkin.ru/index.php/heartjournal/article/view/442 |
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