Two Interconvertible Folds Modulate the Activity of a DNA Aptamer Against Transferrin Receptor

Two Interconvertible Folds Modulate the Activity of a DNA Aptamer Against Transferrin Receptor

Thanks to their ability to recognize biomolecular targets with high affinity and specificity, nucleic acid aptamers are increasingly investigated as diagnostic and therapeutic tools, particularly when their targets are cell-surface receptors. Here, we investigate the relationship between the folding...

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Bibliographic Details
Main Authors: David Porciani, Giovanni Signore, Laura Marchetti, Paolo Mereghetti, Riccardo Nifosì, Fabio Beltram
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
aptamer folding
aptamer-mediated endocytosis
aptamer rational engineering
transferrin receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116302839

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