Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms
Bergapten is a furanocoumarin naturally occurring in the Apiaceae family and it is a well-known photosensitizing agent used in photochemotherapy. In this study, we investigated the influence of bergapten on cognitive function and mechanism underlying these effects in scopolamine-induced memory impai...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00730/full |
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| author | Joanna Kowalczyk Joanna Kowalczyk Łukasz Kurach Anna Boguszewska-Czubara Krystyna Skalicka-Woźniak Marta Kruk-Słomka Jacek Kurzepa Małgorzata Wydrzynska-Kuźma Grażyna Biała Adrianna Skiba Barbara Budzyńska |
| author_facet | Joanna Kowalczyk Joanna Kowalczyk Łukasz Kurach Anna Boguszewska-Czubara Krystyna Skalicka-Woźniak Marta Kruk-Słomka Jacek Kurzepa Małgorzata Wydrzynska-Kuźma Grażyna Biała Adrianna Skiba Barbara Budzyńska |
| author_sort | Joanna Kowalczyk |
| collection | DOAJ |
| description | Bergapten is a furanocoumarin naturally occurring in the Apiaceae family and it is a well-known photosensitizing agent used in photochemotherapy. In this study, we investigated the influence of bergapten on cognitive function and mechanism underlying these effects in scopolamine-induced memory impairment in male Swiss mice. The passive avoidance test was used to evaluate the efficiency of memory acquisition and consolidation. The results demonstrated that both single and repeated administration of bergapten improved not only the acquisition but also consolidation of memory. The behavioral tests showed that bergapten prevented memory impairment induced by administration of scopolamine. Observed effects may result from the inhibition of acetylcholinesterase activity in the hippocampus and prefrontal cortex. Also, bergapten caused significant anti-oxidative effects. These new findings provide pharmacological and biochemical support for the development of the coumarin’s potential in cognitive deficits. |
| first_indexed | 2024-12-13T21:42:22Z |
| format | Article |
| id | doaj.art-e8a610f7e6764a47864d474ee5b9ef2b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T21:42:22Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-e8a610f7e6764a47864d474ee5b9ef2b2022-12-21T23:30:30ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-08-011410.3389/fnins.2020.00730544831Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative MechanismsJoanna Kowalczyk0Joanna Kowalczyk1Łukasz Kurach2Anna Boguszewska-Czubara3Krystyna Skalicka-Woźniak4Marta Kruk-Słomka5Jacek Kurzepa6Małgorzata Wydrzynska-Kuźma7Grażyna Biała8Adrianna Skiba9Barbara Budzyńska10Chair and Department of Applied Pharmacy, Medical University of Lublin, Lublin, PolandIndependent Laboratory of Behavioral Studies, Medical University of Lublin, Lublin, PolandIndependent Laboratory of Behavioral Studies, Medical University of Lublin, Lublin, PolandChair and Department of Medicinal Chemistry, Medical University of Lublin, Lublin, PolandChair and Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, Lublin, PolandChair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, PolandChair and Department of Medicinal Chemistry, Medical University of Lublin, Lublin, PolandChair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, PolandChair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, PolandChair and Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, Lublin, PolandIndependent Laboratory of Behavioral Studies, Medical University of Lublin, Lublin, PolandBergapten is a furanocoumarin naturally occurring in the Apiaceae family and it is a well-known photosensitizing agent used in photochemotherapy. In this study, we investigated the influence of bergapten on cognitive function and mechanism underlying these effects in scopolamine-induced memory impairment in male Swiss mice. The passive avoidance test was used to evaluate the efficiency of memory acquisition and consolidation. The results demonstrated that both single and repeated administration of bergapten improved not only the acquisition but also consolidation of memory. The behavioral tests showed that bergapten prevented memory impairment induced by administration of scopolamine. Observed effects may result from the inhibition of acetylcholinesterase activity in the hippocampus and prefrontal cortex. Also, bergapten caused significant anti-oxidative effects. These new findings provide pharmacological and biochemical support for the development of the coumarin’s potential in cognitive deficits.https://www.frontiersin.org/article/10.3389/fnins.2020.00730/fullacetylcholineoxidative stresscoumarinsmemorypassive avoidance |
| spellingShingle | Joanna Kowalczyk Joanna Kowalczyk Łukasz Kurach Anna Boguszewska-Czubara Krystyna Skalicka-Woźniak Marta Kruk-Słomka Jacek Kurzepa Małgorzata Wydrzynska-Kuźma Grażyna Biała Adrianna Skiba Barbara Budzyńska Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms Frontiers in Neuroscience acetylcholine oxidative stress coumarins memory passive avoidance |
| title | Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms |
| title_full | Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms |
| title_fullStr | Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms |
| title_full_unstemmed | Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms |
| title_short | Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms |
| title_sort | bergapten improves scopolamine induced memory impairment in mice via cholinergic and antioxidative mechanisms |
| topic | acetylcholine oxidative stress coumarins memory passive avoidance |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00730/full |
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