The age, NT-proBNP, and Ejection Fraction Score as a Novel Predictor of Clinical Outcomes in CAD Patients After PCI
Background Previous evidences have been proved that age, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and ejection fraction are tightly associated with the long-term outcomes in patients suffered from coronary artery disease (CAD). Therefore, the present study aimed to assess the prognosis...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-07-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296221113345 |
| _version_ | 1811223080452751360 |
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| author | Lei Fan MD Zeng-Lei Zhang MD Jun-Nan Tang PhD Qian-Qian Guo MD Jian-Chao Zhang MD Meng-Die Cheng MD Feng-Hua Song MD Zhi-Yu Liu MD Kai Wang MD Li-Zhu Jiang MD Xiao-Ting Yue MD Yan Bai MD Xin-Ya Dai MD Ru-Jie Zheng MD Ying-Ying Zheng PhD Jin-Ying Zhang PhD |
| author_facet | Lei Fan MD Zeng-Lei Zhang MD Jun-Nan Tang PhD Qian-Qian Guo MD Jian-Chao Zhang MD Meng-Die Cheng MD Feng-Hua Song MD Zhi-Yu Liu MD Kai Wang MD Li-Zhu Jiang MD Xiao-Ting Yue MD Yan Bai MD Xin-Ya Dai MD Ru-Jie Zheng MD Ying-Ying Zheng PhD Jin-Ying Zhang PhD |
| author_sort | Lei Fan MD |
| collection | DOAJ |
| description | Background Previous evidences have been proved that age, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and ejection fraction are tightly associated with the long-term outcomes in patients suffered from coronary artery disease (CAD). Therefore, the present study aimed to assess the prognosis value of age, NT-proBNP, and ejection fraction (ABEF) score in CAD patients who underwent percutaneous coronary intervention (PCI). Methods Observational cohort methodology was used in this study which enrolled totally 3561 patients. And the patients were followed up regularly for 37.59 ± 22.24 months. Patients were classed into three groups based on the tertiles of ABEF sore: first tertile (<5.06, n = 831), second tertile (5.06-6.25, n = 839), and third tertile (≥ 6.25, n = 834). The ABEF score was calculated as follows: age (years)/ejection fraction (%) + NT-proBNP (NT-proBNP<177pg/mL was 1, 177≤NT-proBNP≥524pg/mL was 2 and NT-proBNP > 524pg/mL is 3). The association between ABEF score and adverse prognosis, including all-cause death (ACD), cardiac death (CD), major adverse cardiovascular events (MACEs) and major adverse cardiac and cerebrovascular events (MACCEs), in patients who underwent PCI was analyzed. Results According to the risk category of ABEF score, the incidences of ACD ( P < .001), CD ( P < .001) and MACCEs ( P = .021) among the three groups showed significant differences. Multivariate Cox regression analysis suggested that the respective risks of ACD and CD were increased 3.013 folds (hazard risk [HR] = 4.013 [95% confidence interval [CI]: 1.922-8.378], P < .001) and 4.922 folds ([HR] = 5.922 [95% [CI]: 2.253-15.566], P < .001) in the third tertile compared with those in the first tertile. Kaplan-Meier survival analyses showed that the cumulative risks of ACD,CD and MACCEs in patients with the high ABEF score tended to increase. Conclusion The present study indicated ABEF score was a novel biomarker suitable for predicting adverse prognosis in patients after PCI, which may be used for early recognition and risk stratification. |
| first_indexed | 2024-04-12T08:25:56Z |
| format | Article |
| id | doaj.art-e8a668340836494f8d3611751d73fdc1 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-04-12T08:25:56Z |
| publishDate | 2022-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-e8a668340836494f8d3611751d73fdc12022-12-22T03:40:23ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232022-07-012810.1177/10760296221113345The age, NT-proBNP, and Ejection Fraction Score as a Novel Predictor of Clinical Outcomes in CAD Patients After PCILei Fan MD0Zeng-Lei Zhang MD1Jun-Nan Tang PhD2Qian-Qian Guo MD3Jian-Chao Zhang MD4Meng-Die Cheng MD5Feng-Hua Song MD6Zhi-Yu Liu MD7Kai Wang MD8Li-Zhu Jiang MD9Xiao-Ting Yue MD10Yan Bai MD11Xin-Ya Dai MD12Ru-Jie Zheng MD13Ying-Ying Zheng PhD14Jin-Ying Zhang PhD15 Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R., China. Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, ChinaBackground Previous evidences have been proved that age, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and ejection fraction are tightly associated with the long-term outcomes in patients suffered from coronary artery disease (CAD). Therefore, the present study aimed to assess the prognosis value of age, NT-proBNP, and ejection fraction (ABEF) score in CAD patients who underwent percutaneous coronary intervention (PCI). Methods Observational cohort methodology was used in this study which enrolled totally 3561 patients. And the patients were followed up regularly for 37.59 ± 22.24 months. Patients were classed into three groups based on the tertiles of ABEF sore: first tertile (<5.06, n = 831), second tertile (5.06-6.25, n = 839), and third tertile (≥ 6.25, n = 834). The ABEF score was calculated as follows: age (years)/ejection fraction (%) + NT-proBNP (NT-proBNP<177pg/mL was 1, 177≤NT-proBNP≥524pg/mL was 2 and NT-proBNP > 524pg/mL is 3). The association between ABEF score and adverse prognosis, including all-cause death (ACD), cardiac death (CD), major adverse cardiovascular events (MACEs) and major adverse cardiac and cerebrovascular events (MACCEs), in patients who underwent PCI was analyzed. Results According to the risk category of ABEF score, the incidences of ACD ( P < .001), CD ( P < .001) and MACCEs ( P = .021) among the three groups showed significant differences. Multivariate Cox regression analysis suggested that the respective risks of ACD and CD were increased 3.013 folds (hazard risk [HR] = 4.013 [95% confidence interval [CI]: 1.922-8.378], P < .001) and 4.922 folds ([HR] = 5.922 [95% [CI]: 2.253-15.566], P < .001) in the third tertile compared with those in the first tertile. Kaplan-Meier survival analyses showed that the cumulative risks of ACD,CD and MACCEs in patients with the high ABEF score tended to increase. Conclusion The present study indicated ABEF score was a novel biomarker suitable for predicting adverse prognosis in patients after PCI, which may be used for early recognition and risk stratification.https://doi.org/10.1177/10760296221113345 |
| spellingShingle | Lei Fan MD Zeng-Lei Zhang MD Jun-Nan Tang PhD Qian-Qian Guo MD Jian-Chao Zhang MD Meng-Die Cheng MD Feng-Hua Song MD Zhi-Yu Liu MD Kai Wang MD Li-Zhu Jiang MD Xiao-Ting Yue MD Yan Bai MD Xin-Ya Dai MD Ru-Jie Zheng MD Ying-Ying Zheng PhD Jin-Ying Zhang PhD The age, NT-proBNP, and Ejection Fraction Score as a Novel Predictor of Clinical Outcomes in CAD Patients After PCI Clinical and Applied Thrombosis/Hemostasis |
| title | The age, NT-proBNP, and Ejection Fraction Score as a Novel Predictor of Clinical Outcomes in CAD Patients After PCI |
| title_full | The age, NT-proBNP, and Ejection Fraction Score as a Novel Predictor of Clinical Outcomes in CAD Patients After PCI |
| title_fullStr | The age, NT-proBNP, and Ejection Fraction Score as a Novel Predictor of Clinical Outcomes in CAD Patients After PCI |
| title_full_unstemmed | The age, NT-proBNP, and Ejection Fraction Score as a Novel Predictor of Clinical Outcomes in CAD Patients After PCI |
| title_short | The age, NT-proBNP, and Ejection Fraction Score as a Novel Predictor of Clinical Outcomes in CAD Patients After PCI |
| title_sort | age nt probnp and ejection fraction score as a novel predictor of clinical outcomes in cad patients after pci |
| url | https://doi.org/10.1177/10760296221113345 |
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