Multi-disciplinary treatment of undifferentiated embryonal sarcoma of the liver with tumor embolus extending to the heart
Undifferentiated embryonal sarcoma of the liver (UESL) is a highly malignant neoplasm occurring predominantly in children. Complete resection is the only curative treatment. We encountered an 11-year-old boy with UESL arising in the right lobe of the liver extending to the pulmonary valve. He was tr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-03-01
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| Series: | Journal of Pediatric Surgery Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213576620303390 |
| _version_ | 1831551877634850816 |
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| author | Kunio Fukuda Ai Yoshimi Miki Toma Satoru Matsushima Norihiko Kitagawa Masato Shinkai Noritaka Ota Toshihide Asou Mio Tanaka Yukichi Tanaka Chie Kobayashi Takayuki Masuko Asai Nobuyoshi Keisuke Kato Junko Shiono Haruo Ohtani Kazutoshi Koike Tatsuo Kono Toshihiro Yanai Masahiro Tsuchida |
| author_facet | Kunio Fukuda Ai Yoshimi Miki Toma Satoru Matsushima Norihiko Kitagawa Masato Shinkai Noritaka Ota Toshihide Asou Mio Tanaka Yukichi Tanaka Chie Kobayashi Takayuki Masuko Asai Nobuyoshi Keisuke Kato Junko Shiono Haruo Ohtani Kazutoshi Koike Tatsuo Kono Toshihiro Yanai Masahiro Tsuchida |
| author_sort | Kunio Fukuda |
| collection | DOAJ |
| description | Undifferentiated embryonal sarcoma of the liver (UESL) is a highly malignant neoplasm occurring predominantly in children. Complete resection is the only curative treatment. We encountered an 11-year-old boy with UESL arising in the right lobe of the liver extending to the pulmonary valve. He was treated with IREC (irinotecan, etoposide, and carboplatin) neoadjuvant chemotherapy, concurrent extended radical right hepatectomy, and intracardiac tumorectomy under cardiopulmonary bypass, and adjuvant IREC chemotherapy. He remains in remission without complications 48 months after diagnosis. Multidisciplinary treatment, particularly the combination of radical surgery and effective neoadjuvant chemotherapy, may contribute to UESL patients' survival. |
| first_indexed | 2024-12-17T03:16:54Z |
| format | Article |
| id | doaj.art-e8a6d906df0c4e0f8119209e131a5c24 |
| institution | Directory Open Access Journal |
| issn | 2213-5766 |
| language | English |
| last_indexed | 2024-12-17T03:16:54Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pediatric Surgery Case Reports |
| spelling | doaj.art-e8a6d906df0c4e0f8119209e131a5c242022-12-21T22:05:38ZengElsevierJournal of Pediatric Surgery Case Reports2213-57662021-03-0166101705Multi-disciplinary treatment of undifferentiated embryonal sarcoma of the liver with tumor embolus extending to the heartKunio Fukuda0Ai Yoshimi1Miki Toma2Satoru Matsushima3Norihiko Kitagawa4Masato Shinkai5Noritaka Ota6Toshihide Asou7Mio Tanaka8Yukichi Tanaka9Chie Kobayashi10Takayuki Masuko11Asai Nobuyoshi12Keisuke Kato13Junko Shiono14Haruo Ohtani15Kazutoshi Koike16Tatsuo Kono17Toshihiro Yanai18Masahiro Tsuchida19Divisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, JapanDivisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan; Divisions of Institute of Pediatric Medicine and Cancer Research, Ibaraki Children's Hospital, Mito, JapanDivisions of Pediatric Surgery, Ibaraki Children's Hospital, Mito, JapanDivisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, JapanDivisions of Pediatric Surgery, Kanagawa Children's Medical Center, Yokohama, JapanDivisions of Pediatric Surgery, Kanagawa Children's Medical Center, Yokohama, JapanDivisions of Cardiovascular Surgery, Kanagawa Children's Medical Center, Yokohama, Japan; Division of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Ehime, JapanDivisions of Cardiovascular Surgery, Kanagawa Children's Medical Center, Yokohama, JapanDivisions of Pediatric Pathology, Kanagawa Children's Medical Center, Yokohama, JapanDivisions of Pediatric Pathology, Kanagawa Children's Medical Center, Yokohama, JapanDivisions of General Pediatrics, Ibaraki Children's Hospital, Mito, JapanDivisions of Pediatric Surgery, Ibaraki Children's Hospital, Mito, JapanDivisions of Clinical Laboratory, Ibaraki Children's Hospital, Mito, JapanDivisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan; Divisions of Institute of Pediatric Medicine and Cancer Research, Ibaraki Children's Hospital, Mito, Japan; Corresponding author. Division of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Futaba-dai 3-3-1, Mito, Ibaraki, 311-4145, Japan.Divisions of Pediatric Cardiology, Ibaraki Children's Hospital, Mito, JapanDivisions of Pediatric Pathology, Ibaraki Children's Hospital, Mito, JapanDivisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan; Divisions of Institute of Pediatric Medicine and Cancer Research, Ibaraki Children's Hospital, Mito, JapanDivision of Clinical Radiology, Tokyo Metropolitan Children's Medical Center, Fuchu, Tokyo, JapanDivisions of Pediatric Surgery, Ibaraki Children's Hospital, Mito, JapanDivisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, JapanUndifferentiated embryonal sarcoma of the liver (UESL) is a highly malignant neoplasm occurring predominantly in children. Complete resection is the only curative treatment. We encountered an 11-year-old boy with UESL arising in the right lobe of the liver extending to the pulmonary valve. He was treated with IREC (irinotecan, etoposide, and carboplatin) neoadjuvant chemotherapy, concurrent extended radical right hepatectomy, and intracardiac tumorectomy under cardiopulmonary bypass, and adjuvant IREC chemotherapy. He remains in remission without complications 48 months after diagnosis. Multidisciplinary treatment, particularly the combination of radical surgery and effective neoadjuvant chemotherapy, may contribute to UESL patients' survival.http://www.sciencedirect.com/science/article/pii/S2213576620303390Undifferentiated embryonal sarcoma of the liverIRECMultidisciplinary treatment |
| spellingShingle | Kunio Fukuda Ai Yoshimi Miki Toma Satoru Matsushima Norihiko Kitagawa Masato Shinkai Noritaka Ota Toshihide Asou Mio Tanaka Yukichi Tanaka Chie Kobayashi Takayuki Masuko Asai Nobuyoshi Keisuke Kato Junko Shiono Haruo Ohtani Kazutoshi Koike Tatsuo Kono Toshihiro Yanai Masahiro Tsuchida Multi-disciplinary treatment of undifferentiated embryonal sarcoma of the liver with tumor embolus extending to the heart Journal of Pediatric Surgery Case Reports Undifferentiated embryonal sarcoma of the liver IREC Multidisciplinary treatment |
| title | Multi-disciplinary treatment of undifferentiated embryonal sarcoma of the liver with tumor embolus extending to the heart |
| title_full | Multi-disciplinary treatment of undifferentiated embryonal sarcoma of the liver with tumor embolus extending to the heart |
| title_fullStr | Multi-disciplinary treatment of undifferentiated embryonal sarcoma of the liver with tumor embolus extending to the heart |
| title_full_unstemmed | Multi-disciplinary treatment of undifferentiated embryonal sarcoma of the liver with tumor embolus extending to the heart |
| title_short | Multi-disciplinary treatment of undifferentiated embryonal sarcoma of the liver with tumor embolus extending to the heart |
| title_sort | multi disciplinary treatment of undifferentiated embryonal sarcoma of the liver with tumor embolus extending to the heart |
| topic | Undifferentiated embryonal sarcoma of the liver IREC Multidisciplinary treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2213576620303390 |
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