Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity
Abstract Objective: Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Jornal de Pediatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000600521&lng=en&tlng=en |
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| author | Patrícia de Araújo Pereira António Marcos Alvim-Soares Jr. Valéria Cristina Sandrim Carla Márcia Moreira Lanna Débora Cristine Souza-Costa Vanessa de Almeida Belo Jonas Jardim de Paula José Eduardo Tanus-Santos Marco Aurélio Romano-Silva Débora Marques de Miranda |
| author_facet | Patrícia de Araújo Pereira António Marcos Alvim-Soares Jr. Valéria Cristina Sandrim Carla Márcia Moreira Lanna Débora Cristine Souza-Costa Vanessa de Almeida Belo Jonas Jardim de Paula José Eduardo Tanus-Santos Marco Aurélio Romano-Silva Débora Marques de Miranda |
| author_sort | Patrícia de Araújo Pereira |
| collection | DOAJ |
| description | Abstract Objective: Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance. Methods: This was a case-control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects. Results: As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies. Conclusion: The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed. |
| first_indexed | 2024-04-13T05:01:14Z |
| format | Article |
| id | doaj.art-e8a725185669423088056ad3c1fb9269 |
| institution | Directory Open Access Journal |
| issn | 1678-4782 |
| language | English |
| last_indexed | 2024-04-13T05:01:14Z |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj.art-e8a725185669423088056ad3c1fb92692022-12-22T03:01:19ZengElsevierJornal de Pediatria1678-478292552152710.1016/j.jped.2015.12.007S0021-75572016000600521Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesityPatrícia de Araújo PereiraAntónio Marcos Alvim-Soares Jr.Valéria Cristina SandrimCarla Márcia Moreira LannaDébora Cristine Souza-CostaVanessa de Almeida BeloJonas Jardim de PaulaJosé Eduardo Tanus-SantosMarco Aurélio Romano-SilvaDébora Marques de MirandaAbstract Objective: Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance. Methods: This was a case-control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects. Results: As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies. Conclusion: The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000600521&lng=en&tlng=enSingle-nucleotide polymorphismsChildhood obesityFat mass and obesity associatedGeneAKT1AKTIP |
| spellingShingle | Patrícia de Araújo Pereira António Marcos Alvim-Soares Jr. Valéria Cristina Sandrim Carla Márcia Moreira Lanna Débora Cristine Souza-Costa Vanessa de Almeida Belo Jonas Jardim de Paula José Eduardo Tanus-Santos Marco Aurélio Romano-Silva Débora Marques de Miranda Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity Jornal de Pediatria Single-nucleotide polymorphisms Childhood obesity Fat mass and obesity associated Gene AKT1 AKTIP |
| title | Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| title_full | Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| title_fullStr | Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| title_full_unstemmed | Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| title_short | Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity |
| title_sort | lack of association between genetic polymorphism of fto akt1 and aktip in childhood overweight and obesity |
| topic | Single-nucleotide polymorphisms Childhood obesity Fat mass and obesity associated Gene AKT1 AKTIP |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000600521&lng=en&tlng=en |
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