CusS-CusR Two-Component System Mediates Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae

CusS-CusR Two-Component System Mediates Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae

BackgroundThe increase in carbapenem-resistant Klebsiella pneumoniae (CRKP), especially the emergence of tigecycline-resistant K. pneumoniae (KP), is a serious public health concern. However, the underlying mechanism of tigecycline resistance is unclear. In this study, we evaluated the role of the C...

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Bibliographic Details
Main Authors: Dongjie Chen, Yunan Zhao, Yanqin Qiu, Liying Xiao, Huaqiang He, Dongmei Zheng, Xiaoqin Li, Xiaoli Yu, Nengluan Xu, Xinlan Hu, Falin Chen, Hongru Li, Yusheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Microbiology
Subjects:
Klebsiella pneumoniae
carbapenem resistance
tigecycline resistance
CusS-CusR two-component system
RNA sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.03159/full

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