The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review
Iron is an indispensable nutrient for life. A lack of it leads to iron deficiency anaemia (IDA), which currently affects about 1.2 billion people worldwide. The primary means of IDA treatment is oral or parenteral iron supplementation. This can be burdened with numerous side effects such as oxidativ...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/17/3478 |
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| author | Ida J. Malesza Joanna Bartkowiak-Wieczorek Jakub Winkler-Galicki Aleksandra Nowicka Dominika Dzięciołowska Marta Błaszczyk Paulina Gajniak Karolina Słowińska Leszek Niepolski Jarosław Walkowiak Edyta Mądry |
| author_facet | Ida J. Malesza Joanna Bartkowiak-Wieczorek Jakub Winkler-Galicki Aleksandra Nowicka Dominika Dzięciołowska Marta Błaszczyk Paulina Gajniak Karolina Słowińska Leszek Niepolski Jarosław Walkowiak Edyta Mądry |
| author_sort | Ida J. Malesza |
| collection | DOAJ |
| description | Iron is an indispensable nutrient for life. A lack of it leads to iron deficiency anaemia (IDA), which currently affects about 1.2 billion people worldwide. The primary means of IDA treatment is oral or parenteral iron supplementation. This can be burdened with numerous side effects such as oxidative stress, systemic and local-intestinal inflammation, dysbiosis, carcinogenic processes and gastrointestinal adverse events. Therefore, this review aimed to provide insight into the physiological mechanisms of iron management and investigate the state of knowledge of the relationship between iron supplementation, inflammatory status and changes in gut microbiota milieu in diseases typically complicated with IDA and considered as having an inflammatory background such as in inflammatory bowel disease, colorectal cancer or obesity. Understanding the precise mechanisms critical to iron metabolism and the awareness of serious adverse effects associated with iron supplementation may lead to the provision of better IDA treatment. Well-planned research, specific to each patient category and disease, is needed to find measures and methods to optimise iron treatment and reduce adverse effects. |
| first_indexed | 2024-03-10T01:26:20Z |
| format | Article |
| id | doaj.art-e8a7ad13e84646a8a14ea3c9f34289cf |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:26:20Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e8a7ad13e84646a8a14ea3c9f34289cf2023-11-23T13:51:05ZengMDPI AGNutrients2072-66432022-08-011417347810.3390/nu14173478The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative ReviewIda J. Malesza0Joanna Bartkowiak-Wieczorek1Jakub Winkler-Galicki2Aleksandra Nowicka3Dominika Dzięciołowska4Marta Błaszczyk5Paulina Gajniak6Karolina Słowińska7Leszek Niepolski8Jarosław Walkowiak9Edyta Mądry10Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Physiology, Poznan University of Medical Sciences, 61-701 Poznan, PolandIron is an indispensable nutrient for life. A lack of it leads to iron deficiency anaemia (IDA), which currently affects about 1.2 billion people worldwide. The primary means of IDA treatment is oral or parenteral iron supplementation. This can be burdened with numerous side effects such as oxidative stress, systemic and local-intestinal inflammation, dysbiosis, carcinogenic processes and gastrointestinal adverse events. Therefore, this review aimed to provide insight into the physiological mechanisms of iron management and investigate the state of knowledge of the relationship between iron supplementation, inflammatory status and changes in gut microbiota milieu in diseases typically complicated with IDA and considered as having an inflammatory background such as in inflammatory bowel disease, colorectal cancer or obesity. Understanding the precise mechanisms critical to iron metabolism and the awareness of serious adverse effects associated with iron supplementation may lead to the provision of better IDA treatment. Well-planned research, specific to each patient category and disease, is needed to find measures and methods to optimise iron treatment and reduce adverse effects.https://www.mdpi.com/2072-6643/14/17/3478inflammatory bowel diseasecolorectal cancerobesityoxidative stressdysbiosisanaemia |
| spellingShingle | Ida J. Malesza Joanna Bartkowiak-Wieczorek Jakub Winkler-Galicki Aleksandra Nowicka Dominika Dzięciołowska Marta Błaszczyk Paulina Gajniak Karolina Słowińska Leszek Niepolski Jarosław Walkowiak Edyta Mądry The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review Nutrients inflammatory bowel disease colorectal cancer obesity oxidative stress dysbiosis anaemia |
| title | The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review |
| title_full | The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review |
| title_fullStr | The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review |
| title_full_unstemmed | The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review |
| title_short | The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia—A Narrative Review |
| title_sort | dark side of iron the relationship between iron inflammation and gut microbiota in selected diseases associated with iron deficiency anaemia a narrative review |
| topic | inflammatory bowel disease colorectal cancer obesity oxidative stress dysbiosis anaemia |
| url | https://www.mdpi.com/2072-6643/14/17/3478 |
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