New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection
ABSTRACT Viruses have evolved many novel mechanisms to promote infection and to mitigate the host cell response to that infection. In the article by M. H. Hancock et al. (mBio 8:e00109-17, 2017, https://doi.org/10.1128/mBio.00109-17 ), the authors describe a new mechanism by which human cytomegalovi...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2017-05-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mBio.00505-17 |
| _version_ | 1819011866268008448 |
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| author | Andrew D. Yurochko |
| author_facet | Andrew D. Yurochko |
| author_sort | Andrew D. Yurochko |
| collection | DOAJ |
| description | ABSTRACT Viruses have evolved many novel mechanisms to promote infection and to mitigate the host cell response to that infection. In the article by M. H. Hancock et al. (mBio 8:e00109-17, 2017, https://doi.org/10.1128/mBio.00109-17 ), the authors describe a new mechanism by which human cytomegalovirus (HCMV) microRNAs (miRNAs; miR-US5-1 and miR-UL112-3p) negate the proinflammatory response to infection. The authors document that these two viral miRNAs downregulate the NF-κB response through direct targeting of the IKKα and IKKβ mRNAs, which in turn, through diminished IκB kinases (IKKs), block production of proinflammatory cytokines (interleukin-6 [IL-6], CCL5, and tumor necrosis factor alpha [TNF-α]). Because most signaling pathways that promote NF-κB activation and nuclear translocation ultimately converge on the activation of the IKK complex, this new study documents that HCMV can strongly dictate how infected cells respond to internal and/or external stimuli and thus positively influence the outcome of both lytic and latent infection. |
| first_indexed | 2024-12-21T01:34:58Z |
| format | Article |
| id | doaj.art-e8a7e69c78b848978e80a3ac3187d5a5 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-21T01:34:58Z |
| publishDate | 2017-05-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-e8a7e69c78b848978e80a3ac3187d5a52022-12-21T19:20:17ZengAmerican Society for MicrobiologymBio2150-75112017-05-018210.1128/mBio.00505-17New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to InfectionAndrew D. Yurochko0Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USAABSTRACT Viruses have evolved many novel mechanisms to promote infection and to mitigate the host cell response to that infection. In the article by M. H. Hancock et al. (mBio 8:e00109-17, 2017, https://doi.org/10.1128/mBio.00109-17 ), the authors describe a new mechanism by which human cytomegalovirus (HCMV) microRNAs (miRNAs; miR-US5-1 and miR-UL112-3p) negate the proinflammatory response to infection. The authors document that these two viral miRNAs downregulate the NF-κB response through direct targeting of the IKKα and IKKβ mRNAs, which in turn, through diminished IκB kinases (IKKs), block production of proinflammatory cytokines (interleukin-6 [IL-6], CCL5, and tumor necrosis factor alpha [TNF-α]). Because most signaling pathways that promote NF-κB activation and nuclear translocation ultimately converge on the activation of the IKK complex, this new study documents that HCMV can strongly dictate how infected cells respond to internal and/or external stimuli and thus positively influence the outcome of both lytic and latent infection.https://journals.asm.org/doi/10.1128/mBio.00505-17HCMVIKKNF-κBcytokineshuman cytomegalovirusmiRNA |
| spellingShingle | Andrew D. Yurochko New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection mBio HCMV IKK NF-κB cytokines human cytomegalovirus miRNA |
| title | New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection |
| title_full | New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection |
| title_fullStr | New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection |
| title_full_unstemmed | New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection |
| title_short | New Mechanism by Which Human Cytomegalovirus MicroRNAs Negate the Proinflammatory Response to Infection |
| title_sort | new mechanism by which human cytomegalovirus micrornas negate the proinflammatory response to infection |
| topic | HCMV IKK NF-κB cytokines human cytomegalovirus miRNA |
| url | https://journals.asm.org/doi/10.1128/mBio.00505-17 |
| work_keys_str_mv | AT andrewdyurochko newmechanismbywhichhumancytomegalovirusmicrornasnegatetheproinflammatoryresponsetoinfection |