Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy
Abstract We report a 54‐year‐old man with treatment‐resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly, the patient has a DIO2 polymorphism.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-04-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.5651 |
| _version_ | 1811288576092012544 |
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| author | Ziyan S. Ahmed Rinsha P. V. Sherin Tatiana L. Fonseca Thanh D. Hoang Mohamed K. M. Shakir |
| author_facet | Ziyan S. Ahmed Rinsha P. V. Sherin Tatiana L. Fonseca Thanh D. Hoang Mohamed K. M. Shakir |
| author_sort | Ziyan S. Ahmed |
| collection | DOAJ |
| description | Abstract We report a 54‐year‐old man with treatment‐resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly, the patient has a DIO2 polymorphism. |
| first_indexed | 2024-04-13T03:39:18Z |
| format | Article |
| id | doaj.art-e8a99ff56b324aad8776c46410c4a45a |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-04-13T03:39:18Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-e8a99ff56b324aad8776c46410c4a45a2022-12-22T03:04:13ZengWileyClinical Case Reports2050-09042022-04-01104n/an/a10.1002/ccr3.5651Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 TherapyZiyan S. Ahmed0Rinsha P. V. Sherin1Tatiana L. Fonseca2Thanh D. Hoang3Mohamed K. M. Shakir4Endocrinology Division Walter Reed National Military Medical Center Bethesda Maryland USAEndocrinology Division Walter Reed National Military Medical Center Bethesda Maryland USASection of Adult and Pediatric Endocrinology Diabetes & Metabolism University of Chicago Chicago Illinois USAEndocrinology Division Walter Reed National Military Medical Center Bethesda Maryland USAEndocrinology Division Walter Reed National Military Medical Center Bethesda Maryland USAAbstract We report a 54‐year‐old man with treatment‐resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly, the patient has a DIO2 polymorphism.https://doi.org/10.1002/ccr3.5651depressionhypothyroidismpolymorphismT3 |
| spellingShingle | Ziyan S. Ahmed Rinsha P. V. Sherin Tatiana L. Fonseca Thanh D. Hoang Mohamed K. M. Shakir Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy Clinical Case Reports depression hypothyroidism polymorphism T3 |
| title | Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy |
| title_full | Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy |
| title_fullStr | Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy |
| title_full_unstemmed | Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy |
| title_short | Improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with LT3 Therapy |
| title_sort | improvement of depression in a patient with hypothyroidism and deiodinase polymorphism with lt3 therapy |
| topic | depression hypothyroidism polymorphism T3 |
| url | https://doi.org/10.1002/ccr3.5651 |
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