Dexmedetomidine, an alpha 2A receptor agonist, triggers seizures unilaterally in GAERS during the pre-epileptic phase: does the onset of spike-and-wave discharges occur in a focal manner?

Dexmedetomidine, an alpha 2A receptor agonist, triggers seizures unilaterally in GAERS during the pre-epileptic phase: does the onset of spike-and-wave discharges occur in a focal manner?

IntroductionThe genetic absence epilepsy rat from Strasbourg (GAERS) is a rat model for infantile absence epilepsy with spike-and-wave discharges (SWDs). This study aimed to investigate the potential of alpha 2A agonism to induce seizures during the pre-epileptic period in GAERS rats.MethodsStereota...

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Bibliographic Details
Main Authors: Melis Yavuz, Pelin İyiköşker, Nursima Mutlu, Serra Kiliçparlar, Öykü Hazal Şalci, Gökçen Dolu, Elif Nur Kaymakçilar, Serdar Akkol, Filiz Onat
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Neurology
Subjects:
GAERS
spike-and-wave discharges
unilateral seizures
α2AAR
pre-epileptic
dexmedetomidine
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1231736/full

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