Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults
BackgroundOligomeric Aβ (OAβ) is a promising candidate marker for Alzheimer’s disease (AD) diagnosis. Electroencephalography (EEG) is a potential tool for early detection of AD. Still, whether EEG power ratios, particularly the theta/alpha ratio (TAR) and theta/beta ratio (TBR), reflect Aβ burden—a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1291881/full |
| _version_ | 1797435147256070144 |
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| author | Heewon Bae Heewon Bae Min Ju Kang Sang-Won Ha Da-Eun Jeong Kiwon Lee Seungui Lim Jin-Young Min Kyoung-Bok Min Kyoung-Bok Min |
| author_facet | Heewon Bae Heewon Bae Min Ju Kang Sang-Won Ha Da-Eun Jeong Kiwon Lee Seungui Lim Jin-Young Min Kyoung-Bok Min Kyoung-Bok Min |
| author_sort | Heewon Bae |
| collection | DOAJ |
| description | BackgroundOligomeric Aβ (OAβ) is a promising candidate marker for Alzheimer’s disease (AD) diagnosis. Electroencephalography (EEG) is a potential tool for early detection of AD. Still, whether EEG power ratios, particularly the theta/alpha ratio (TAR) and theta/beta ratio (TBR), reflect Aβ burden—a primary mechanism underlying cognitive impairment and AD. This study investigated the association of TAR and TBR with amyloid burden in older adults based on MDS-OAβ levels.Methods529 individuals (aged ≥60 years) were recruited. All participants underwent EEG (MINDD SCAN, Ybrain Inc., South Korea) and AlzOn™ test (PeopleBio Inc., Gyeonggi-do, Republic of Korea) for quantifying MDS-OAβ values in the plasma. EEG variables were log-transformed to normalize the data distribution. Using the MDS-OAβ cutoff value (0.78 ng/mL), all participants were classified into two groups: high MDS-OAβ and low MDS-OAβ.ResultsParticipants with high MDS-OAβ levels had significantly higher TARs and TBRs than those with low MDS-OAβ levels. The log-transformed TBRs in the central lobe (β = 0.161, p = 0.0026), frontal lobe (β = 0.145, p = 0.0044), parietal lobe (β = 0.166, p = 0.0028), occipital lobe (β = 0.158, p = 0.0058), and temporal lobe (beta = 0.162, p = 0.0042) were significantly and positively associated with increases in MDS-OAβ levels. After adjusting for the Bonferroni correction, the TBRs in all lobe regions, except the occipital lobe, were significantly associated with increased MDS-OAβ levels.ConclusionWe found a significant association of MDS-OAβ with TBR in older adults. This finding indicates that an increase in amyloid burden may be associated with an increase in the low-frequency band and a decrease in the relatively high-frequency band. |
| first_indexed | 2024-03-09T10:43:03Z |
| format | Article |
| id | doaj.art-e8ac0a5e174245b28cfbcdab3e18ac80 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-09T10:43:03Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-e8ac0a5e174245b28cfbcdab3e18ac802023-12-01T12:28:44ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-12-011510.3389/fnagi.2023.12918811291881Association of plasma amyloid-β oligomerization with theta/beta ratio in older adultsHeewon Bae0Heewon Bae1Min Ju Kang2Sang-Won Ha3Da-Eun Jeong4Kiwon Lee5Seungui Lim6Jin-Young Min7Kyoung-Bok Min8Kyoung-Bok Min9Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Republic of KoreaDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Republic of KoreaDepartment of Neurology, Veterans Health Service Medical Center, Seoul, Republic of KoreaDepartment of Neurology, Veterans Health Service Medical Center, Seoul, Republic of KoreaDepartment of Neurology, Veterans Health Service Medical Center, Seoul, Republic of KoreaYbrain Research Institute, Seongnam-si, Republic of KoreaYbrain Research Institute, Seongnam-si, Republic of KoreaVeterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Republic of KoreaDepartment of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of KoreaMedical Research Center, Institute of Health Policy and Management, Seoul National University, Seoul, Republic of KoreaBackgroundOligomeric Aβ (OAβ) is a promising candidate marker for Alzheimer’s disease (AD) diagnosis. Electroencephalography (EEG) is a potential tool for early detection of AD. Still, whether EEG power ratios, particularly the theta/alpha ratio (TAR) and theta/beta ratio (TBR), reflect Aβ burden—a primary mechanism underlying cognitive impairment and AD. This study investigated the association of TAR and TBR with amyloid burden in older adults based on MDS-OAβ levels.Methods529 individuals (aged ≥60 years) were recruited. All participants underwent EEG (MINDD SCAN, Ybrain Inc., South Korea) and AlzOn™ test (PeopleBio Inc., Gyeonggi-do, Republic of Korea) for quantifying MDS-OAβ values in the plasma. EEG variables were log-transformed to normalize the data distribution. Using the MDS-OAβ cutoff value (0.78 ng/mL), all participants were classified into two groups: high MDS-OAβ and low MDS-OAβ.ResultsParticipants with high MDS-OAβ levels had significantly higher TARs and TBRs than those with low MDS-OAβ levels. The log-transformed TBRs in the central lobe (β = 0.161, p = 0.0026), frontal lobe (β = 0.145, p = 0.0044), parietal lobe (β = 0.166, p = 0.0028), occipital lobe (β = 0.158, p = 0.0058), and temporal lobe (beta = 0.162, p = 0.0042) were significantly and positively associated with increases in MDS-OAβ levels. After adjusting for the Bonferroni correction, the TBRs in all lobe regions, except the occipital lobe, were significantly associated with increased MDS-OAβ levels.ConclusionWe found a significant association of MDS-OAβ with TBR in older adults. This finding indicates that an increase in amyloid burden may be associated with an increase in the low-frequency band and a decrease in the relatively high-frequency band.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1291881/fullamyloid oligomersEEGAlzheimer’s diseasecognitive impairmentneurotox |
| spellingShingle | Heewon Bae Heewon Bae Min Ju Kang Sang-Won Ha Da-Eun Jeong Kiwon Lee Seungui Lim Jin-Young Min Kyoung-Bok Min Kyoung-Bok Min Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults Frontiers in Aging Neuroscience amyloid oligomers EEG Alzheimer’s disease cognitive impairment neurotox |
| title | Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults |
| title_full | Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults |
| title_fullStr | Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults |
| title_full_unstemmed | Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults |
| title_short | Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults |
| title_sort | association of plasma amyloid β oligomerization with theta beta ratio in older adults |
| topic | amyloid oligomers EEG Alzheimer’s disease cognitive impairment neurotox |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1291881/full |
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