α-Adducin gene promoter DNA methylation and the risk of essential hypertension
This study was conducted to test the association between promoter DNA methylation of α-Adducin (ADD1) gene and the risk of essential hypertension (EH). A total of 150 EH patients and 100 aged- and gender-matched controls were investigated. DNA methylation levels of five cytosine-phosphate-guanine (C...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-11-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2017.1324481 |
| _version_ | 1797681553005871104 |
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| author | Nervana M. K. Bayoumy Mohamed M. El-Shabrawi Ola Farouk Leheta Hamdy Hassan Omar |
| author_facet | Nervana M. K. Bayoumy Mohamed M. El-Shabrawi Ola Farouk Leheta Hamdy Hassan Omar |
| author_sort | Nervana M. K. Bayoumy |
| collection | DOAJ |
| description | This study was conducted to test the association between promoter DNA methylation of α-Adducin (ADD1) gene and the risk of essential hypertension (EH). A total of 150 EH patients and 100 aged- and gender-matched controls were investigated. DNA methylation levels of five cytosine-phosphate-guanine (CpG) dinucleotides on ADD1 promoter were measured employing bisulfite pyrosequencing technology. Our results showed that females have a higher ADD1 DNA methylation than males and a significantly lower CpG1 methylation level is associated with increased risk of EH among them. As for males, a significant association between lower CpG2-5 methylation levels and increased risk of EH was shown. In addition, CpG2-5 methylation was found to be a highly significant predictor for EH among males. In females, CpG1 methylation was considered a predictor of hypertension. No significant correlations were found with biochemical measures, apart from the concentration of aspartate aminotransferase which was inversely correlated with ADD1 CpG2-5 methylation levels among female controls (r = −0.703). These findings highlight that ADD1 methylation may have a contributing role in the pathogenesis of EH with varying implications for both genders. |
| first_indexed | 2024-03-11T23:46:31Z |
| format | Article |
| id | doaj.art-e8addafc73d1452b9d9046e4094a76e0 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:46:31Z |
| publishDate | 2017-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-e8addafc73d1452b9d9046e4094a76e02023-09-19T09:24:46ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062017-11-0139876476810.1080/10641963.2017.13244811324481α-Adducin gene promoter DNA methylation and the risk of essential hypertensionNervana M. K. Bayoumy0Mohamed M. El-Shabrawi1Ola Farouk Leheta2Hamdy Hassan Omar3College of Medicine, Center of Excellence in Thrombosis & Hemostasis, King Saud UniversitySuez Canal UniversitySuez Canal UniversitySuez Canal UniversityThis study was conducted to test the association between promoter DNA methylation of α-Adducin (ADD1) gene and the risk of essential hypertension (EH). A total of 150 EH patients and 100 aged- and gender-matched controls were investigated. DNA methylation levels of five cytosine-phosphate-guanine (CpG) dinucleotides on ADD1 promoter were measured employing bisulfite pyrosequencing technology. Our results showed that females have a higher ADD1 DNA methylation than males and a significantly lower CpG1 methylation level is associated with increased risk of EH among them. As for males, a significant association between lower CpG2-5 methylation levels and increased risk of EH was shown. In addition, CpG2-5 methylation was found to be a highly significant predictor for EH among males. In females, CpG1 methylation was considered a predictor of hypertension. No significant correlations were found with biochemical measures, apart from the concentration of aspartate aminotransferase which was inversely correlated with ADD1 CpG2-5 methylation levels among female controls (r = −0.703). These findings highlight that ADD1 methylation may have a contributing role in the pathogenesis of EH with varying implications for both genders.http://dx.doi.org/10.1080/10641963.2017.1324481cpg dinucleotidedna methylationessential hypertensionsingle nucleotide polymophismα-adducin gene |
| spellingShingle | Nervana M. K. Bayoumy Mohamed M. El-Shabrawi Ola Farouk Leheta Hamdy Hassan Omar α-Adducin gene promoter DNA methylation and the risk of essential hypertension Clinical and Experimental Hypertension cpg dinucleotide dna methylation essential hypertension single nucleotide polymophism α-adducin gene |
| title | α-Adducin gene promoter DNA methylation and the risk of essential hypertension |
| title_full | α-Adducin gene promoter DNA methylation and the risk of essential hypertension |
| title_fullStr | α-Adducin gene promoter DNA methylation and the risk of essential hypertension |
| title_full_unstemmed | α-Adducin gene promoter DNA methylation and the risk of essential hypertension |
| title_short | α-Adducin gene promoter DNA methylation and the risk of essential hypertension |
| title_sort | α adducin gene promoter dna methylation and the risk of essential hypertension |
| topic | cpg dinucleotide dna methylation essential hypertension single nucleotide polymophism α-adducin gene |
| url | http://dx.doi.org/10.1080/10641963.2017.1324481 |
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