Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study
Abstract Background Cerebral stroke (CS) is the leading cause of death in China, and a complex disease caused by both alterable risk factors and genetic factors. This study intended to investigate the association of MMP3, MMP14, and MMP25 single nucleotide polymorphisms (SNPs) with CS risk in a Chin...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Medical Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12920-023-01734-1 |
| _version_ | 1797451159835770880 |
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| author | Yanling Yin Yu Zhang Xiaobo Zhang Qi Zhang Jiachen Wang Tian Yang Chen Liang Wu Li Jie Liu Xiaojuan Ma Jinwei Duan Wenzhen Shi Ye Tian |
| author_facet | Yanling Yin Yu Zhang Xiaobo Zhang Qi Zhang Jiachen Wang Tian Yang Chen Liang Wu Li Jie Liu Xiaojuan Ma Jinwei Duan Wenzhen Shi Ye Tian |
| author_sort | Yanling Yin |
| collection | DOAJ |
| description | Abstract Background Cerebral stroke (CS) is the leading cause of death in China, and a complex disease caused by both alterable risk factors and genetic factors. This study intended to investigate the association of MMP3, MMP14, and MMP25 single nucleotide polymorphisms (SNPs) with CS risk in a Chinese Han population. Methods A total of 1,348 Han Chinese were recruited in this case-control study. Four candidate loci including rs520540 A/G and rs679620 T/C of MMP3, rs2236302 G/C of MMP14, and rs10431961 T/C of MMP25 were successfully screened. The correlation between the four SNPs and CS risk was assessed by logistic regression analysis. The results were analyzed by false-positive report probability (FPRP) for chance or significance. The interactions between four SNPs associated with CS risk were assessed by multifactor dimensionality reduction (MDR). Results rs520540 A/G and rs679620 C/T SNP in MMP3 were associated with risk of CS in allele, codominant, dominant and log-additive models. Ischemic stroke risk were significantly lower in carriers with rs520540-A allele and rs679620-T allele than those with G/G or C/C genotypes. However, rs520540-A allele and rs679620-T allele were associated with higher risk of hemorrhagic stroke. Stratified analysis showed that these two SNPs were associated with reduced risk of CS in aged < 55 years, non-smoking and non-drinking participants, and rs679620 SNP also reduced CS risk in male participants. The levels of uric acid, high-density lipoprotein cholesterol, and eosinophil were different among patients with different genotypes of rs520540 and rs679620. No statistically significant association was found between MMP14 rs2236302 G/C or MMP25 rs10431961 T/C with CS even after stratification by stroke subtypes, age, gender as well as smoking and drinking conditions in all the genetic models. Conclusion MMP3 rs520540 A/G and rs679620 C/T polymorphisms were associated with CS risk in the Chinese Han population, which provides useful information for the prevention and diagnosis of CS. |
| first_indexed | 2024-03-09T14:50:48Z |
| format | Article |
| id | doaj.art-e8ae4a70f4224595923d2c1c8d5048f5 |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-03-09T14:50:48Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-e8ae4a70f4224595923d2c1c8d5048f52023-11-26T14:30:09ZengBMCBMC Medical Genomics1755-87942023-11-0116111310.1186/s12920-023-01734-1Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control studyYanling Yin0Yu Zhang1Xiaobo Zhang2Qi Zhang3Jiachen Wang4Tian Yang5Chen Liang6Wu Li7Jie Liu8Xiaojuan Ma9Jinwei Duan10Wenzhen Shi11Ye Tian12Department of Neurology, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest UniversityThe College of Life Sciences, Northwest UniversityThe College of Life Sciences, Northwest UniversityThe College of Life Sciences, Northwest UniversityThe College of Life Sciences, Northwest UniversityClinical Medical Research Center, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest UniversityClinical Medical Research Center, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest UniversityClinical Medical Research Center, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest UniversityClinical Medical Research Center, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest UniversityClinical Medical Research Center, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest UniversityClinical Medical Research Center, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest UniversityClinical Medical Research Center, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest UniversityAbstract Background Cerebral stroke (CS) is the leading cause of death in China, and a complex disease caused by both alterable risk factors and genetic factors. This study intended to investigate the association of MMP3, MMP14, and MMP25 single nucleotide polymorphisms (SNPs) with CS risk in a Chinese Han population. Methods A total of 1,348 Han Chinese were recruited in this case-control study. Four candidate loci including rs520540 A/G and rs679620 T/C of MMP3, rs2236302 G/C of MMP14, and rs10431961 T/C of MMP25 were successfully screened. The correlation between the four SNPs and CS risk was assessed by logistic regression analysis. The results were analyzed by false-positive report probability (FPRP) for chance or significance. The interactions between four SNPs associated with CS risk were assessed by multifactor dimensionality reduction (MDR). Results rs520540 A/G and rs679620 C/T SNP in MMP3 were associated with risk of CS in allele, codominant, dominant and log-additive models. Ischemic stroke risk were significantly lower in carriers with rs520540-A allele and rs679620-T allele than those with G/G or C/C genotypes. However, rs520540-A allele and rs679620-T allele were associated with higher risk of hemorrhagic stroke. Stratified analysis showed that these two SNPs were associated with reduced risk of CS in aged < 55 years, non-smoking and non-drinking participants, and rs679620 SNP also reduced CS risk in male participants. The levels of uric acid, high-density lipoprotein cholesterol, and eosinophil were different among patients with different genotypes of rs520540 and rs679620. No statistically significant association was found between MMP14 rs2236302 G/C or MMP25 rs10431961 T/C with CS even after stratification by stroke subtypes, age, gender as well as smoking and drinking conditions in all the genetic models. Conclusion MMP3 rs520540 A/G and rs679620 C/T polymorphisms were associated with CS risk in the Chinese Han population, which provides useful information for the prevention and diagnosis of CS.https://doi.org/10.1186/s12920-023-01734-1Cerebral StrokeCase-control studyMMP3MMP14MMP25Single nucleotide polymorphisms |
| spellingShingle | Yanling Yin Yu Zhang Xiaobo Zhang Qi Zhang Jiachen Wang Tian Yang Chen Liang Wu Li Jie Liu Xiaojuan Ma Jinwei Duan Wenzhen Shi Ye Tian Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study BMC Medical Genomics Cerebral Stroke Case-control study MMP3 MMP14 MMP25 Single nucleotide polymorphisms |
| title | Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study |
| title_full | Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study |
| title_fullStr | Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study |
| title_full_unstemmed | Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study |
| title_short | Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study |
| title_sort | association of mmp3 mmp14 and mmp25 gene polymorphisms with cerebral stroke risk a case control study |
| topic | Cerebral Stroke Case-control study MMP3 MMP14 MMP25 Single nucleotide polymorphisms |
| url | https://doi.org/10.1186/s12920-023-01734-1 |
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