Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches
Parkinson's disease (PD) is the most common neurodegenerative movement disorder in the elderly. As the pathogenesis of PD is still not fully understood, medications with the capacity of halting the disease progression are currently unavailable. The discovery of genes that are causative for, or...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-05-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304222000095 |
| _version_ | 1797700765414850560 |
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| author | Yue Huang Jun Wei Antony Cooper Margaret J. Morris |
| author_facet | Yue Huang Jun Wei Antony Cooper Margaret J. Morris |
| author_sort | Yue Huang |
| collection | DOAJ |
| description | Parkinson's disease (PD) is the most common neurodegenerative movement disorder in the elderly. As the pathogenesis of PD is still not fully understood, medications with the capacity of halting the disease progression are currently unavailable. The discovery of genes that are causative for, or increase susceptibility to PD is pivotal for the development of novel therapeutic approaches, as they are critical for the onset of PD and the molecular pathways underlying its pathogenesis. By reviewing relevant data, we discuss causative genes, and those associated with PD susceptibility and quantitative traits. Through Gene Ontology database and STRING analysis, we emphasize the roles of inorganic cation transmembrane transport pathways and hypothalamic pituitary thyroid axis, in addition to the established roles of inflammation/oxidative stress and mitochondrial dysfunction in the pathogenesis of PD. It is hoped these insights 1) untangle the clinical complex presentations of PD, 2) reveal the interwoven molecular network leading to PD, and 3) identify critical molecular targets to facilitate novel PD drug discovery, with a view to providing improved consultation and personalized medicine for patients with PD in the future. |
| first_indexed | 2024-03-12T04:26:22Z |
| format | Article |
| id | doaj.art-e8b419dcf79b41209e9e70c9cff6d74f |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T04:26:22Z |
| publishDate | 2023-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-e8b419dcf79b41209e9e70c9cff6d74f2023-09-03T10:20:57ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422023-05-01103786798Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approachesYue Huang0Jun Wei1Antony Cooper2Margaret J. Morris3China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Department of Pharmacology, School of Medical Sciences, Faculty of Medicine & Health, UNSW, Sydney, NSW 2052, Australia; Corresponding author. No. 119, South Forth Ring West Road, Fengtai District, Beijing 100070, China. Fax: +86 10 5997 5698.Department of Pharmacology, School of Medical Sciences, Faculty of Medicine & Health, UNSW, Sydney, NSW 2052, AustraliaThe Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St Vincent's Clinical School, Faculty of Medicine & Health, and School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW, Sydney, NSW 2052, AustraliaDepartment of Pharmacology, School of Medical Sciences, Faculty of Medicine & Health, UNSW, Sydney, NSW 2052, AustraliaParkinson's disease (PD) is the most common neurodegenerative movement disorder in the elderly. As the pathogenesis of PD is still not fully understood, medications with the capacity of halting the disease progression are currently unavailable. The discovery of genes that are causative for, or increase susceptibility to PD is pivotal for the development of novel therapeutic approaches, as they are critical for the onset of PD and the molecular pathways underlying its pathogenesis. By reviewing relevant data, we discuss causative genes, and those associated with PD susceptibility and quantitative traits. Through Gene Ontology database and STRING analysis, we emphasize the roles of inorganic cation transmembrane transport pathways and hypothalamic pituitary thyroid axis, in addition to the established roles of inflammation/oxidative stress and mitochondrial dysfunction in the pathogenesis of PD. It is hoped these insights 1) untangle the clinical complex presentations of PD, 2) reveal the interwoven molecular network leading to PD, and 3) identify critical molecular targets to facilitate novel PD drug discovery, with a view to providing improved consultation and personalized medicine for patients with PD in the future.http://www.sciencedirect.com/science/article/pii/S2352304222000095Drug discoveryGeneticsMolecular functionParkinson's diseaseQuantitative traits |
| spellingShingle | Yue Huang Jun Wei Antony Cooper Margaret J. Morris Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches Genes and Diseases Drug discovery Genetics Molecular function Parkinson's disease Quantitative traits |
| title | Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches |
| title_full | Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches |
| title_fullStr | Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches |
| title_full_unstemmed | Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches |
| title_short | Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches |
| title_sort | parkinson s disease from genetics to molecular dysfunction and targeted therapeutic approaches |
| topic | Drug discovery Genetics Molecular function Parkinson's disease Quantitative traits |
| url | http://www.sciencedirect.com/science/article/pii/S2352304222000095 |
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