Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions
Retinal vein occlusions (RVOs) are the second most common retinal vascular disease after diabetic retinopathy, and are a significant cause of visual impairment, especially in the elderly population. RVOs result in visual loss due to macular ischemia, cystoid macular edema (CME), and complications re...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1110166/full |
| _version_ | 1797808988805398528 |
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| author | Tien-En Tan Tien-En Tan Farah Ibrahim Priya R. Chandrasekaran Kelvin Yi Chong Teo Kelvin Yi Chong Teo |
| author_facet | Tien-En Tan Tien-En Tan Farah Ibrahim Priya R. Chandrasekaran Kelvin Yi Chong Teo Kelvin Yi Chong Teo |
| author_sort | Tien-En Tan |
| collection | DOAJ |
| description | Retinal vein occlusions (RVOs) are the second most common retinal vascular disease after diabetic retinopathy, and are a significant cause of visual impairment, especially in the elderly population. RVOs result in visual loss due to macular ischemia, cystoid macular edema (CME), and complications related to neovascularization. Vascular assessment in RVOs traditionally relies on standard fluorescein angiography (FA) for assessment of macular and retinal ischemia, which aids in prognostication and guides intervention. Standard FA has significant limitations—it is time-consuming, requires invasive dye administration, allows for limited assessment of the peripheral retina, and is usually evaluated semi-qualitatively, by ophthalmologists with tertiary expertise. More recently, the introduction of ultra-widefield FA (UWF FA) and optical coherence tomography angiography (OCTA) into clinical practice has changed the tools available for vascular evaluation in RVOs. UWF FA allows for evaluation of peripheral retinal perfusion, and OCTA is non-invasive, rapidly-acquired, and provides more information on capillary perfusion. Both modalities can be used to provide more quantitative parameters related to retinal perfusion. In this article, we review the clinical utility and impact of UWF FA and OCTA in the evaluation and management of patients with RVOs. |
| first_indexed | 2024-03-13T06:45:53Z |
| format | Article |
| id | doaj.art-e8b46a05d57b44698e7caf7fa6b42178 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T06:45:53Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-e8b46a05d57b44698e7caf7fa6b421782023-06-08T06:15:58ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-06-011010.3389/fmed.2023.11101661110166Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusionsTien-En Tan0Tien-En Tan1Farah Ibrahim2Priya R. Chandrasekaran3Kelvin Yi Chong Teo4Kelvin Yi Chong Teo5Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, SingaporeDuke-NUS Medical School, Singapore, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, SingaporeDuke-NUS Medical School, Singapore, SingaporeRetinal vein occlusions (RVOs) are the second most common retinal vascular disease after diabetic retinopathy, and are a significant cause of visual impairment, especially in the elderly population. RVOs result in visual loss due to macular ischemia, cystoid macular edema (CME), and complications related to neovascularization. Vascular assessment in RVOs traditionally relies on standard fluorescein angiography (FA) for assessment of macular and retinal ischemia, which aids in prognostication and guides intervention. Standard FA has significant limitations—it is time-consuming, requires invasive dye administration, allows for limited assessment of the peripheral retina, and is usually evaluated semi-qualitatively, by ophthalmologists with tertiary expertise. More recently, the introduction of ultra-widefield FA (UWF FA) and optical coherence tomography angiography (OCTA) into clinical practice has changed the tools available for vascular evaluation in RVOs. UWF FA allows for evaluation of peripheral retinal perfusion, and OCTA is non-invasive, rapidly-acquired, and provides more information on capillary perfusion. Both modalities can be used to provide more quantitative parameters related to retinal perfusion. In this article, we review the clinical utility and impact of UWF FA and OCTA in the evaluation and management of patients with RVOs.https://www.frontiersin.org/articles/10.3389/fmed.2023.1110166/fullbranch retinal vein occlusion (BRVO)central retinal vein occlusion (CRVO)ultra-widefield (UWF)optical coherence tomography angiography (OCTA)fluorescein angiography (FA)retinal imaging |
| spellingShingle | Tien-En Tan Tien-En Tan Farah Ibrahim Priya R. Chandrasekaran Kelvin Yi Chong Teo Kelvin Yi Chong Teo Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions Frontiers in Medicine branch retinal vein occlusion (BRVO) central retinal vein occlusion (CRVO) ultra-widefield (UWF) optical coherence tomography angiography (OCTA) fluorescein angiography (FA) retinal imaging |
| title | Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions |
| title_full | Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions |
| title_fullStr | Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions |
| title_full_unstemmed | Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions |
| title_short | Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions |
| title_sort | clinical utility of ultra widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions |
| topic | branch retinal vein occlusion (BRVO) central retinal vein occlusion (CRVO) ultra-widefield (UWF) optical coherence tomography angiography (OCTA) fluorescein angiography (FA) retinal imaging |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1110166/full |
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