Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy.
Pathological cardiomyocyte hypertrophy is associated with significantly increased risk of heart failure, one of the leading medical causes of mortality worldwide. MicroRNAs are known to be involved in pathological cardiac remodeling. However, whether miR-99a participates in the signaling cascade lea...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4767297?pdf=render |
| _version_ | 1818308911804973056 |
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| author | Qiaoling Li Jun Xie Bingjian Wang Ran Li Jian Bai Liang Ding Rong Gu Lian Wang Biao Xu |
| author_facet | Qiaoling Li Jun Xie Bingjian Wang Ran Li Jian Bai Liang Ding Rong Gu Lian Wang Biao Xu |
| author_sort | Qiaoling Li |
| collection | DOAJ |
| description | Pathological cardiomyocyte hypertrophy is associated with significantly increased risk of heart failure, one of the leading medical causes of mortality worldwide. MicroRNAs are known to be involved in pathological cardiac remodeling. However, whether miR-99a participates in the signaling cascade leading to cardiac hypertrophy is unknown. To evaluate the role of miR-99a in cardiac hypertrophy, we assessed the expression of miR-99a in hypertrophic cardiomyocytes induced by isoprenaline (ISO)/angiotensin-II (Ang II) and in mice model of cardiac hypertrophy induced by transverse aortic constriction (TAC). Expression of miR-99a was evaluated in these hypertrophic cells and hearts. We also found that miR-99a expression was highly correlated with cardiac function of mice with heart failure (8 weeks after TAC surgery). Overexpression of miR-99a attenuated cardiac hypertrophy in TAC mice and cellular hypertrophy in stimuli treated cardiomyocytes through down-regulation of expression of mammalian target of rapamycin (mTOR). These results indicate that miR-99a negatively regulates physiological hypertrophy through mTOR signaling pathway, which may provide a new therapeutic approach for pressure-overload heart failure. |
| first_indexed | 2024-12-13T07:21:48Z |
| format | Article |
| id | doaj.art-e8b496ea62ee4e79b689c87871680a2b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T07:21:48Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e8b496ea62ee4e79b689c87871680a2b2022-12-21T23:55:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014848010.1371/journal.pone.0148480Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy.Qiaoling LiJun XieBingjian WangRan LiJian BaiLiang DingRong GuLian WangBiao XuPathological cardiomyocyte hypertrophy is associated with significantly increased risk of heart failure, one of the leading medical causes of mortality worldwide. MicroRNAs are known to be involved in pathological cardiac remodeling. However, whether miR-99a participates in the signaling cascade leading to cardiac hypertrophy is unknown. To evaluate the role of miR-99a in cardiac hypertrophy, we assessed the expression of miR-99a in hypertrophic cardiomyocytes induced by isoprenaline (ISO)/angiotensin-II (Ang II) and in mice model of cardiac hypertrophy induced by transverse aortic constriction (TAC). Expression of miR-99a was evaluated in these hypertrophic cells and hearts. We also found that miR-99a expression was highly correlated with cardiac function of mice with heart failure (8 weeks after TAC surgery). Overexpression of miR-99a attenuated cardiac hypertrophy in TAC mice and cellular hypertrophy in stimuli treated cardiomyocytes through down-regulation of expression of mammalian target of rapamycin (mTOR). These results indicate that miR-99a negatively regulates physiological hypertrophy through mTOR signaling pathway, which may provide a new therapeutic approach for pressure-overload heart failure.http://europepmc.org/articles/PMC4767297?pdf=render |
| spellingShingle | Qiaoling Li Jun Xie Bingjian Wang Ran Li Jian Bai Liang Ding Rong Gu Lian Wang Biao Xu Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy. PLoS ONE |
| title | Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy. |
| title_full | Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy. |
| title_fullStr | Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy. |
| title_full_unstemmed | Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy. |
| title_short | Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy. |
| title_sort | overexpression of microrna 99a attenuates cardiac hypertrophy |
| url | http://europepmc.org/articles/PMC4767297?pdf=render |
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