The role of epidermal differentiation gene complex studies in atopic dermatitis
Atopic dermatitis (AD) is a chronic skin disease affecting mainly children with an increasing prevalence worldwide. AD is a complex trait resulting from genetic predisposition, skin barrier dysfunction, immune dysregulation, and environmental factors. The major risk factors for AD are a family histo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-06-01
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| Series: | Turkderm Turkish Archives of Dermatology and Venereology |
| Subjects: | |
| Online Access: | https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-23326&look4= |
| Summary: | Atopic dermatitis (AD) is a chronic skin disease affecting mainly children with an increasing prevalence worldwide. AD is a complex trait resulting from genetic predisposition, skin barrier dysfunction, immune dysregulation, and environmental factors. The major risk factors for AD are a family history of atopy (eczema, asthma, or allergic rhinitis) and the loss-of-function mutations in the filaggrin (FLG) gene. This review highlights the role of the genetic abnormalities identified in AD, from the susceptibility loci in genome-wide associations to epigenetic studies. |
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| ISSN: | 2651-5164 |