The role of epidermal differentiation gene complex studies in atopic dermatitis
Atopic dermatitis (AD) is a chronic skin disease affecting mainly children with an increasing prevalence worldwide. AD is a complex trait resulting from genetic predisposition, skin barrier dysfunction, immune dysregulation, and environmental factors. The major risk factors for AD are a family histo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-06-01
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| Series: | Turkderm Turkish Archives of Dermatology and Venereology |
| Subjects: | |
| Online Access: | https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-23326&look4= |
| _version_ | 1797916671704301568 |
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| author | Özge Gündüz Deepak Modi Raquel Duarte |
| author_facet | Özge Gündüz Deepak Modi Raquel Duarte |
| author_sort | Özge Gündüz |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a chronic skin disease affecting mainly children with an increasing prevalence worldwide. AD is a complex trait resulting from genetic predisposition, skin barrier dysfunction, immune dysregulation, and environmental factors. The major risk factors for AD are a family history of atopy (eczema, asthma, or allergic rhinitis) and the loss-of-function mutations in the filaggrin (FLG) gene. This review highlights the role of the genetic abnormalities identified in AD, from the susceptibility loci in genome-wide associations to epigenetic studies. |
| first_indexed | 2024-04-10T13:01:03Z |
| format | Article |
| id | doaj.art-e8b5275ede7d46e68a973da77d09b700 |
| institution | Directory Open Access Journal |
| issn | 2651-5164 |
| language | English |
| last_indexed | 2024-04-10T13:01:03Z |
| publishDate | 2021-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkderm Turkish Archives of Dermatology and Venereology |
| spelling | doaj.art-e8b5275ede7d46e68a973da77d09b7002023-02-15T16:13:12ZengGalenos Publishing HouseTurkderm Turkish Archives of Dermatology and Venereology2651-51642021-06-01552566010.4274/turkderm.galenos.2020.23326The role of epidermal differentiation gene complex studies in atopic dermatitisÖzge Gündüz0https://orcid.org/0000-0001-8541-9246Deepak Modi1https://orcid.org/0000-0002-1165-5673Raquel Duarte2https://orcid.org/0000-0003-2750-2062University of the Witwatersrand Faculty of Health Sciences, Department of Internal Medicine, Division of Dermatology, Johannesburg, South AfricaUniversity of the Witwatersrand Faculty of Health Sciences, Department of Internal Medicine, Division of Dermatology, Johannesburg, South AfricaUniversity of the Witwatersrand Faculty of Health Sciences, Department of Internal Medicine, Internal Medicine Research Laboratory, Johannesburg, South AfricaAtopic dermatitis (AD) is a chronic skin disease affecting mainly children with an increasing prevalence worldwide. AD is a complex trait resulting from genetic predisposition, skin barrier dysfunction, immune dysregulation, and environmental factors. The major risk factors for AD are a family history of atopy (eczema, asthma, or allergic rhinitis) and the loss-of-function mutations in the filaggrin (FLG) gene. This review highlights the role of the genetic abnormalities identified in AD, from the susceptibility loci in genome-wide associations to epigenetic studies.https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-23326&look4=atopic dermatitisgeneticsepidermal differentiation gene complexfilaggrin |
| spellingShingle | Özge Gündüz Deepak Modi Raquel Duarte The role of epidermal differentiation gene complex studies in atopic dermatitis Turkderm Turkish Archives of Dermatology and Venereology atopic dermatitis genetics epidermal differentiation gene complex filaggrin |
| title | The role of epidermal differentiation gene complex studies in atopic dermatitis |
| title_full | The role of epidermal differentiation gene complex studies in atopic dermatitis |
| title_fullStr | The role of epidermal differentiation gene complex studies in atopic dermatitis |
| title_full_unstemmed | The role of epidermal differentiation gene complex studies in atopic dermatitis |
| title_short | The role of epidermal differentiation gene complex studies in atopic dermatitis |
| title_sort | role of epidermal differentiation gene complex studies in atopic dermatitis |
| topic | atopic dermatitis genetics epidermal differentiation gene complex filaggrin |
| url | https://journal.turkderm.org.tr/jvi.aspx?pdir=turkderm&plng=eng&un=TURKDERM-23326&look4= |
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