Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context

Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context

Members of the bacterial T6SS amidase effector (Tae) superfamily of toxins are delivered between competing bacteria to degrade cell wall peptidoglycan. Although Taes share a common substrate, they exhibit distinct antimicrobial potency across different competitor species. To investigate the molecula...

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Bibliographic Details
Main Authors: Atanas Radkov, Anne L Sapiro, Sebastian Flores, Corey Henderson, Hayden Saunders, Rachel Kim, Steven Massa, Samuel Thompson, Chase Mateusiak, Jacob Biboy, Ziyi Zhao, Lea M Starita, William L Hatleberg, Waldemar Vollmer, Alistair B Russell, Jean-Pierre Simorre, Spencer Anthony-Cahill, Peter Brzovic, Beth Hayes, Seemay Chou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
type VI amidase effector
peptidoglycan
topology
cognate immunity
deep mutational scanning
host–microbe interaction
Online Access:https://elifesciences.org/articles/79796

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