Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms
Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (<i>Phaeophyta</i>), but it can be also isolated from invertebrates such as sea urchins (<i>Echinoidea</i>) and sea cucumbers (<i...
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MDPI AG
2019-08-01
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Series: | Marine Drugs |
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Online Access: | https://www.mdpi.com/1660-3397/17/8/458 |
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author | Aleksandra Citkowska Marta Szekalska Katarzyna Winnicka |
author_facet | Aleksandra Citkowska Marta Szekalska Katarzyna Winnicka |
author_sort | Aleksandra Citkowska |
collection | DOAJ |
description | Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (<i>Phaeophyta</i>), but it can be also isolated from invertebrates such as sea urchins (<i>Echinoidea</i>) and sea cucumbers (<i>Holothuroidea</i>). Interest in fucoidan is related to its broad biological activity, including possible antioxidant, anti-inflammatory, antifungal, antiviral or antithrombotic effects. The potential application of fucoidan in the pharmaceutical technology is also due to its ionic nature. The negative charge of the molecule results from the presence of sulfate residues in the C-2 and C-4 positions, occasionally in C-3, allowing the formation of complexes with other oppositely charged molecules. Fucoidan is non-toxic, biodegradable and biocompatible compound approved by Food and Drug Administration (FDA) as Generally Recognized As Safe (GRAS) category as food ingredient. Fucoidan plays an important role in the pharmaceutical technology, so in this work aspects concerning its pharmaceutical characteristics and designing of various dosage forms (nanoparticles, liposomes, microparticles, and semisolid formulations) with fucoidan itself and with its combinations with other polymers or components that give a positive charge were reviewed. Advantages and limitations of fucoidan utilization in the pharmaceutical technology were also discussed. |
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id | doaj.art-e8b8feeee47241fa87dfd6d5ef872782 |
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issn | 1660-3397 |
language | English |
last_indexed | 2024-04-11T11:02:26Z |
publishDate | 2019-08-01 |
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series | Marine Drugs |
spelling | doaj.art-e8b8feeee47241fa87dfd6d5ef8727822022-12-22T04:28:31ZengMDPI AGMarine Drugs1660-33972019-08-0117845810.3390/md17080458md17080458Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage FormsAleksandra Citkowska0Marta Szekalska1Katarzyna Winnicka2Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, PolandDepartment of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, PolandDepartment of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, PolandFucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (<i>Phaeophyta</i>), but it can be also isolated from invertebrates such as sea urchins (<i>Echinoidea</i>) and sea cucumbers (<i>Holothuroidea</i>). Interest in fucoidan is related to its broad biological activity, including possible antioxidant, anti-inflammatory, antifungal, antiviral or antithrombotic effects. The potential application of fucoidan in the pharmaceutical technology is also due to its ionic nature. The negative charge of the molecule results from the presence of sulfate residues in the C-2 and C-4 positions, occasionally in C-3, allowing the formation of complexes with other oppositely charged molecules. Fucoidan is non-toxic, biodegradable and biocompatible compound approved by Food and Drug Administration (FDA) as Generally Recognized As Safe (GRAS) category as food ingredient. Fucoidan plays an important role in the pharmaceutical technology, so in this work aspects concerning its pharmaceutical characteristics and designing of various dosage forms (nanoparticles, liposomes, microparticles, and semisolid formulations) with fucoidan itself and with its combinations with other polymers or components that give a positive charge were reviewed. Advantages and limitations of fucoidan utilization in the pharmaceutical technology were also discussed.https://www.mdpi.com/1660-3397/17/8/458polysaccharidemarine-derivedfucoidanpharmaceutical formulationsmultifunctional polymerfucospheres |
spellingShingle | Aleksandra Citkowska Marta Szekalska Katarzyna Winnicka Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms Marine Drugs polysaccharide marine-derived fucoidan pharmaceutical formulations multifunctional polymer fucospheres |
title | Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms |
title_full | Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms |
title_fullStr | Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms |
title_full_unstemmed | Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms |
title_short | Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms |
title_sort | possibilities of fucoidan utilization in the development of pharmaceutical dosage forms |
topic | polysaccharide marine-derived fucoidan pharmaceutical formulations multifunctional polymer fucospheres |
url | https://www.mdpi.com/1660-3397/17/8/458 |
work_keys_str_mv | AT aleksandracitkowska possibilitiesoffucoidanutilizationinthedevelopmentofpharmaceuticaldosageforms AT martaszekalska possibilitiesoffucoidanutilizationinthedevelopmentofpharmaceuticaldosageforms AT katarzynawinnicka possibilitiesoffucoidanutilizationinthedevelopmentofpharmaceuticaldosageforms |