Biosynthesis and Chemical Synthesis of Albomycin Nucleoside Antibiotics
The widespread emergence of antibiotic-resistant bacteria highlights the urgent need for new antimicrobial agents. Albomycins are a group of naturally occurring sideromycins with a thionucleoside antibiotic conjugated to a ferrichrome-type siderophore. The siderophore moiety serves as a vehicle to d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/4/438 |
| _version_ | 1797437201386045440 |
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| author | Meiyan Wang Yuxin Zhang Lanxin Lv Dekun Kong Guoqing Niu |
| author_facet | Meiyan Wang Yuxin Zhang Lanxin Lv Dekun Kong Guoqing Niu |
| author_sort | Meiyan Wang |
| collection | DOAJ |
| description | The widespread emergence of antibiotic-resistant bacteria highlights the urgent need for new antimicrobial agents. Albomycins are a group of naturally occurring sideromycins with a thionucleoside antibiotic conjugated to a ferrichrome-type siderophore. The siderophore moiety serves as a vehicle to deliver albomycins into bacterial cells via a “Trojan horse” strategy. Albomycins function as specific inhibitors of seryl-tRNA synthetases and exhibit potent antimicrobial activities against both Gram-negative and Gram-positive bacteria, including many clinical pathogens. These distinctive features make albomycins promising drug candidates for the treatment of various bacterial infections, especially those caused by multidrug-resistant pathogens. We herein summarize findings on the discovery and structure elucidation, mechanism of action, biosynthesis and immunity, and chemical synthesis of albomcyins, with special focus on recent advances in the biosynthesis and chemical synthesis over the past decade (2012–2022). A thorough understanding of the biosynthetic pathway provides the basis for pathway engineering and combinatorial biosynthesis to create new albomycin analogues. Chemical synthesis of natural congeners and their synthetic analogues will be useful for systematic structure–activity relationship (SAR) studies, and thereby assist the design of novel albomycin-derived antimicrobial agents. |
| first_indexed | 2024-03-09T11:16:25Z |
| format | Article |
| id | doaj.art-e8c13af337ec4dae85378d432056abfc |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T11:16:25Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-e8c13af337ec4dae85378d432056abfc2023-12-01T00:31:46ZengMDPI AGAntibiotics2079-63822022-03-0111443810.3390/antibiotics11040438Biosynthesis and Chemical Synthesis of Albomycin Nucleoside AntibioticsMeiyan Wang0Yuxin Zhang1Lanxin Lv2Dekun Kong3Guoqing Niu4Biotechnology Research Center, Southwest University, Chongqing 400715, ChinaBiotechnology Research Center, Southwest University, Chongqing 400715, ChinaBiotechnology Research Center, Southwest University, Chongqing 400715, ChinaBiotechnology Research Center, Southwest University, Chongqing 400715, ChinaBiotechnology Research Center, Southwest University, Chongqing 400715, ChinaThe widespread emergence of antibiotic-resistant bacteria highlights the urgent need for new antimicrobial agents. Albomycins are a group of naturally occurring sideromycins with a thionucleoside antibiotic conjugated to a ferrichrome-type siderophore. The siderophore moiety serves as a vehicle to deliver albomycins into bacterial cells via a “Trojan horse” strategy. Albomycins function as specific inhibitors of seryl-tRNA synthetases and exhibit potent antimicrobial activities against both Gram-negative and Gram-positive bacteria, including many clinical pathogens. These distinctive features make albomycins promising drug candidates for the treatment of various bacterial infections, especially those caused by multidrug-resistant pathogens. We herein summarize findings on the discovery and structure elucidation, mechanism of action, biosynthesis and immunity, and chemical synthesis of albomcyins, with special focus on recent advances in the biosynthesis and chemical synthesis over the past decade (2012–2022). A thorough understanding of the biosynthetic pathway provides the basis for pathway engineering and combinatorial biosynthesis to create new albomycin analogues. Chemical synthesis of natural congeners and their synthetic analogues will be useful for systematic structure–activity relationship (SAR) studies, and thereby assist the design of novel albomycin-derived antimicrobial agents.https://www.mdpi.com/2079-6382/11/4/438antibiotic resistancealbomycinmode of actionbiosynthesisself-resistancechemical synthesis |
| spellingShingle | Meiyan Wang Yuxin Zhang Lanxin Lv Dekun Kong Guoqing Niu Biosynthesis and Chemical Synthesis of Albomycin Nucleoside Antibiotics Antibiotics antibiotic resistance albomycin mode of action biosynthesis self-resistance chemical synthesis |
| title | Biosynthesis and Chemical Synthesis of Albomycin Nucleoside Antibiotics |
| title_full | Biosynthesis and Chemical Synthesis of Albomycin Nucleoside Antibiotics |
| title_fullStr | Biosynthesis and Chemical Synthesis of Albomycin Nucleoside Antibiotics |
| title_full_unstemmed | Biosynthesis and Chemical Synthesis of Albomycin Nucleoside Antibiotics |
| title_short | Biosynthesis and Chemical Synthesis of Albomycin Nucleoside Antibiotics |
| title_sort | biosynthesis and chemical synthesis of albomycin nucleoside antibiotics |
| topic | antibiotic resistance albomycin mode of action biosynthesis self-resistance chemical synthesis |
| url | https://www.mdpi.com/2079-6382/11/4/438 |
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