The impact of endotrophin on the progression of chronic liver disease
Liver disease: Collagen fragment spurs liver inflammation and fibrosis Localized buildup in the liver of a collagen-derived cleavage fragment plays a critical role in accelerating the development of tissue scarring and liver cancer in mice. Using a transgenic mouse model of fatty liver disease, a te...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-10-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-020-00520-8 |
| _version_ | 1818427422154948608 |
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| author | Min Kim Changhu Lee Dae Yun Seo Hyojung Lee Jay D. Horton Jiyoung Park Philipp E. Scherer |
| author_facet | Min Kim Changhu Lee Dae Yun Seo Hyojung Lee Jay D. Horton Jiyoung Park Philipp E. Scherer |
| author_sort | Min Kim |
| collection | DOAJ |
| description | Liver disease: Collagen fragment spurs liver inflammation and fibrosis Localized buildup in the liver of a collagen-derived cleavage fragment plays a critical role in accelerating the development of tissue scarring and liver cancer in mice. Using a transgenic mouse model of fatty liver disease, a team led by Philipp Scherer from the University of Texas Southwestern Medical Center, Dallas, USA, and Jiyoung Park of Ulsan National Institute of Science and Technology, South Korea, showed that liver-specific accumulation of a collagen fragment known as endotrophin leads to activation of inflammatory and fibrotic pathways. The mice subsequently develop metabolic dysfunction, insulin resistance and, with time, cancerous nodules in the liver. The findings suggest that endotrophin accumulation, when it occurs in liver tissue that already contains large depositions of fat, can overwhelm normal liver physiology and accelerate organ damage. |
| first_indexed | 2024-12-14T14:45:28Z |
| format | Article |
| id | doaj.art-e8c15da804804675993b7404515a3f3a |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-14T14:45:28Z |
| publishDate | 2020-10-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-e8c15da804804675993b7404515a3f3a2022-12-21T22:57:17ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-10-0152101766177610.1038/s12276-020-00520-8The impact of endotrophin on the progression of chronic liver diseaseMin Kim0Changhu Lee1Dae Yun Seo2Hyojung Lee3Jay D. Horton4Jiyoung Park5Philipp E. Scherer6Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and TechnologyDepartment of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and TechnologyCardiovascular and Metabolic Disease Center, Department of Physiology, College of Medicine, Inje UniversityDepartment of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and TechnologyDepartment of Molecular Genetics, and Center for Human Nutrition, University of Texas Southwestern Medical CenterDepartment of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and TechnologyTouchstone Diabetes Center, Department of Internal Medicine, and Department of Cell Biology, University of Texas Southwestern Medical CenterLiver disease: Collagen fragment spurs liver inflammation and fibrosis Localized buildup in the liver of a collagen-derived cleavage fragment plays a critical role in accelerating the development of tissue scarring and liver cancer in mice. Using a transgenic mouse model of fatty liver disease, a team led by Philipp Scherer from the University of Texas Southwestern Medical Center, Dallas, USA, and Jiyoung Park of Ulsan National Institute of Science and Technology, South Korea, showed that liver-specific accumulation of a collagen fragment known as endotrophin leads to activation of inflammatory and fibrotic pathways. The mice subsequently develop metabolic dysfunction, insulin resistance and, with time, cancerous nodules in the liver. The findings suggest that endotrophin accumulation, when it occurs in liver tissue that already contains large depositions of fat, can overwhelm normal liver physiology and accelerate organ damage.https://doi.org/10.1038/s12276-020-00520-8 |
| spellingShingle | Min Kim Changhu Lee Dae Yun Seo Hyojung Lee Jay D. Horton Jiyoung Park Philipp E. Scherer The impact of endotrophin on the progression of chronic liver disease Experimental and Molecular Medicine |
| title | The impact of endotrophin on the progression of chronic liver disease |
| title_full | The impact of endotrophin on the progression of chronic liver disease |
| title_fullStr | The impact of endotrophin on the progression of chronic liver disease |
| title_full_unstemmed | The impact of endotrophin on the progression of chronic liver disease |
| title_short | The impact of endotrophin on the progression of chronic liver disease |
| title_sort | impact of endotrophin on the progression of chronic liver disease |
| url | https://doi.org/10.1038/s12276-020-00520-8 |
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