Regulation of PP2A by Sphingolipid Metabolism and Signaling
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that is a primary regulator of cellular proliferation through targeting of proliferative kinases, cell cycle regulators, and apoptosis inhibitors. It is through the regulation of these regulatory elements that gives PP2A tumor suppresso...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00388/full |
| _version_ | 1819147940782931968 |
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| author | Joshua eOaks Besim eOgretmen |
| author_facet | Joshua eOaks Besim eOgretmen |
| author_sort | Joshua eOaks |
| collection | DOAJ |
| description | Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that is a primary regulator of cellular proliferation through targeting of proliferative kinases, cell cycle regulators, and apoptosis inhibitors. It is through the regulation of these regulatory elements that gives PP2A tumor suppressor functions. In addition to mutations on the regulatory subunits, the phosphatase/tumor suppressing activity of PP2A is also inhibited in several cancer types due to overexpression or modification of the endogenous PP2A inhibitors such as SET/I2PP2A. This review focuses on the current literature regarding the interactions between the lipid signaling molecules, selectively sphingolipids, and the PP2A inhibitor SET for the regulation of PP2A, and the therapeutic potential of sphingolipids as PP2A activators for tumor suppression via targeting SET oncoprotein. |
| first_indexed | 2024-12-22T13:37:48Z |
| format | Article |
| id | doaj.art-e8c217fd32574405a79f68316bdf4c65 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T13:37:48Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e8c217fd32574405a79f68316bdf4c652022-12-21T18:24:00ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-01-01410.3389/fonc.2014.00388127225Regulation of PP2A by Sphingolipid Metabolism and SignalingJoshua eOaks0Besim eOgretmen1Medical University of South CarolinaMedical University of South CarolinaProtein phosphatase 2A (PP2A) is a serine/threonine phosphatase that is a primary regulator of cellular proliferation through targeting of proliferative kinases, cell cycle regulators, and apoptosis inhibitors. It is through the regulation of these regulatory elements that gives PP2A tumor suppressor functions. In addition to mutations on the regulatory subunits, the phosphatase/tumor suppressing activity of PP2A is also inhibited in several cancer types due to overexpression or modification of the endogenous PP2A inhibitors such as SET/I2PP2A. This review focuses on the current literature regarding the interactions between the lipid signaling molecules, selectively sphingolipids, and the PP2A inhibitor SET for the regulation of PP2A, and the therapeutic potential of sphingolipids as PP2A activators for tumor suppression via targeting SET oncoprotein.http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00388/fullSphingolipidsceramidePP2AFTY720tumor suppression. |
| spellingShingle | Joshua eOaks Besim eOgretmen Regulation of PP2A by Sphingolipid Metabolism and Signaling Frontiers in Oncology Sphingolipids ceramide PP2A FTY720 tumor suppression. |
| title | Regulation of PP2A by Sphingolipid Metabolism and Signaling |
| title_full | Regulation of PP2A by Sphingolipid Metabolism and Signaling |
| title_fullStr | Regulation of PP2A by Sphingolipid Metabolism and Signaling |
| title_full_unstemmed | Regulation of PP2A by Sphingolipid Metabolism and Signaling |
| title_short | Regulation of PP2A by Sphingolipid Metabolism and Signaling |
| title_sort | regulation of pp2a by sphingolipid metabolism and signaling |
| topic | Sphingolipids ceramide PP2A FTY720 tumor suppression. |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00388/full |
| work_keys_str_mv | AT joshuaeoaks regulationofpp2abysphingolipidmetabolismandsignaling AT besimeogretmen regulationofpp2abysphingolipidmetabolismandsignaling |