Two distinct trajectories of clinical and neurodegeneration events in Parkinson’s disease

Two distinct trajectories of clinical and neurodegeneration events in Parkinson’s disease

Abstract Increasing evidence suggests that Parkinson’s disease (PD) exhibits disparate spatial and temporal patterns of progression. Here we used a machine-learning technique—Subtype and Stage Inference (SuStaIn) — to uncover PD subtypes with distinct trajectories of clinical and neurodegeneration e...

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Bibliographic Details
Main Authors: Cheng Zhou, Linbo Wang, Wei Cheng, JinChao Lv, Xiaojun Guan, Tao Guo, Jingjing Wu, Wei Zhang, Ting Gao, Xiaocao Liu, Xueqin Bai, Haoting Wu, Zhengye Cao, Luyan Gu, Jingwen Chen, Jiaqi Wen, Peiyu Huang, Xiaojun Xu, Baorong Zhang, Jianfeng Feng, Minming Zhang
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00556-3

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