Comparing prognostic value of preoperative platelet indexes in patients with resectable gastric cancer
Abstract The ratio of mean platelet volume (MPV) to count (PC) (MPV/PC) has been applied in the diagnosis and prognosis of various malignancies. However, the prognostic value of MPV/PC in gastric cancer has not been studied yet. This study aims to explore the prognostic value of neutrophil-to-lympho...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-10511-6 |
| _version_ | 1817988695865688064 |
|---|---|
| author | Hongtai Shi Hongsheng Wang Jie Pan Zhenhua Liu Zuoan Li |
| author_facet | Hongtai Shi Hongsheng Wang Jie Pan Zhenhua Liu Zuoan Li |
| author_sort | Hongtai Shi |
| collection | DOAJ |
| description | Abstract The ratio of mean platelet volume (MPV) to count (PC) (MPV/PC) has been applied in the diagnosis and prognosis of various malignancies. However, the prognostic value of MPV/PC in gastric cancer has not been studied yet. This study aims to explore the prognostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), combined neutrophil-platelet score (CNPS), systemic immune-inflammation index (SII) and MPV/PC in patients with resectable gastric cancer. In this study, the medical records of patients with gastric cancer in two centers were retrospectively analyzed. Kaplan–Meier and log-rank were tests applied to analyze the survival differences of patients with various inflammation indexes. A nomogram prognostic model was established to predict the 3- and 5-year survival rate of patients with resectable gastric cancer. In the two cohorts, Kaplan–Meier analysis that the postoperative survival time of gastric cancer patients with low MPV/PC, high NLR, high PLR and high SII was significantly shorter than that of patients with high MPV/PC, low NLR, low PLR or low SII. Compared with NLR, PLR, SII and CNPS, MPV/PC was more accurate in determining the prognosis of patients with gastric cancer than other indexes, and multivariate analysis confirmed that MPV/PC was an independent prognostic factor for patients with resectable gastric cancer. The nomogram model established based on tumor size, TNM stage and MPV/PC was more accurate than TNM stage in predicting the 3- and 5-year survival rate of patients with resectable gastric cancer. Preoperative MPV/PC is a new independent prognostic index and a potential marker for treatment response monitoring in patients with resectable gastric cancer. The nomogram model for postoperative prognosis of gastric cancer established based on MPV/PC, tumor size and TNM stage is helpful for developing more accurate and timely individualized therapeutic regimens. |
| first_indexed | 2024-04-14T00:37:18Z |
| format | Article |
| id | doaj.art-e8ceec5b8d8f4bb1a7ebc12d7e97a781 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-14T00:37:18Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e8ceec5b8d8f4bb1a7ebc12d7e97a7812022-12-22T02:22:20ZengNature PortfolioScientific Reports2045-23222022-04-0112111110.1038/s41598-022-10511-6Comparing prognostic value of preoperative platelet indexes in patients with resectable gastric cancerHongtai Shi0Hongsheng Wang1Jie Pan2Zhenhua Liu3Zuoan Li4Department of Radiation Oncology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng Third People’s HospitalDepartment of Oncology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng Third People’s HospitalDepartment of Interventional Radiology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng Third People’s HospitalDepartment of Radiotherapy, The Yancheng Clinical College of Xuzhou Medical University, The First People’s Hospital of YanchengDepartment of General Surgery, The Yancheng Clinical College of Xuzhou Medical University, The First People’s Hospital of YanchengAbstract The ratio of mean platelet volume (MPV) to count (PC) (MPV/PC) has been applied in the diagnosis and prognosis of various malignancies. However, the prognostic value of MPV/PC in gastric cancer has not been studied yet. This study aims to explore the prognostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), combined neutrophil-platelet score (CNPS), systemic immune-inflammation index (SII) and MPV/PC in patients with resectable gastric cancer. In this study, the medical records of patients with gastric cancer in two centers were retrospectively analyzed. Kaplan–Meier and log-rank were tests applied to analyze the survival differences of patients with various inflammation indexes. A nomogram prognostic model was established to predict the 3- and 5-year survival rate of patients with resectable gastric cancer. In the two cohorts, Kaplan–Meier analysis that the postoperative survival time of gastric cancer patients with low MPV/PC, high NLR, high PLR and high SII was significantly shorter than that of patients with high MPV/PC, low NLR, low PLR or low SII. Compared with NLR, PLR, SII and CNPS, MPV/PC was more accurate in determining the prognosis of patients with gastric cancer than other indexes, and multivariate analysis confirmed that MPV/PC was an independent prognostic factor for patients with resectable gastric cancer. The nomogram model established based on tumor size, TNM stage and MPV/PC was more accurate than TNM stage in predicting the 3- and 5-year survival rate of patients with resectable gastric cancer. Preoperative MPV/PC is a new independent prognostic index and a potential marker for treatment response monitoring in patients with resectable gastric cancer. The nomogram model for postoperative prognosis of gastric cancer established based on MPV/PC, tumor size and TNM stage is helpful for developing more accurate and timely individualized therapeutic regimens.https://doi.org/10.1038/s41598-022-10511-6 |
| spellingShingle | Hongtai Shi Hongsheng Wang Jie Pan Zhenhua Liu Zuoan Li Comparing prognostic value of preoperative platelet indexes in patients with resectable gastric cancer Scientific Reports |
| title | Comparing prognostic value of preoperative platelet indexes in patients with resectable gastric cancer |
| title_full | Comparing prognostic value of preoperative platelet indexes in patients with resectable gastric cancer |
| title_fullStr | Comparing prognostic value of preoperative platelet indexes in patients with resectable gastric cancer |
| title_full_unstemmed | Comparing prognostic value of preoperative platelet indexes in patients with resectable gastric cancer |
| title_short | Comparing prognostic value of preoperative platelet indexes in patients with resectable gastric cancer |
| title_sort | comparing prognostic value of preoperative platelet indexes in patients with resectable gastric cancer |
| url | https://doi.org/10.1038/s41598-022-10511-6 |
| work_keys_str_mv | AT hongtaishi comparingprognosticvalueofpreoperativeplateletindexesinpatientswithresectablegastriccancer AT hongshengwang comparingprognosticvalueofpreoperativeplateletindexesinpatientswithresectablegastriccancer AT jiepan comparingprognosticvalueofpreoperativeplateletindexesinpatientswithresectablegastriccancer AT zhenhualiu comparingprognosticvalueofpreoperativeplateletindexesinpatientswithresectablegastriccancer AT zuoanli comparingprognosticvalueofpreoperativeplateletindexesinpatientswithresectablegastriccancer |