Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
Abstract Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been known that autoimmune diseases and chronic inflammatory disorders are character...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
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| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.173 |
| _version_ | 1826533402935820288 |
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| author | Su Zhang Yang Meng Lian Zhou Lei Qiu Heping Wang Dan Su Bo Zhang Kui‐Ming Chan Junhong Han |
| author_facet | Su Zhang Yang Meng Lian Zhou Lei Qiu Heping Wang Dan Su Bo Zhang Kui‐Ming Chan Junhong Han |
| author_sort | Su Zhang |
| collection | DOAJ |
| description | Abstract Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been known that autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses, leading to excessive and uncontrol tissue inflammation. The dysregulation of epigenetic alterations including DNA methylation, posttranslational modifications to histone proteins, and noncoding RNA expression has been implicated in a host of inflammatory disorders and the immune system. The inflammatory response is considered as a critical trigger of epigenetic alterations that in turn intercede inflammatory actions. Thus, understanding the molecular mechanism that dictates the outcome of targeting epigenetic regulators for inflammatory disease is required for inflammation resolution. In this article, we elucidate the critical role of the nuclear factor‐κB signaling pathway, JAK/STAT signaling pathway, and the NLRP3 inflammasome in chronic inflammatory diseases. And we formulate the relationship between inflammation, coronavirus disease 2019, and human cancers. Additionally, we review the mechanism of epigenetic modifications involved in inflammation and innate immune cells. All that matters is that we propose and discuss the rejuvenation potential of interventions that target epigenetic regulators and regulatory mechanisms for chronic inflammation‐associated diseases to improve therapeutic outcomes. |
| first_indexed | 2024-04-12T03:29:58Z |
| format | Article |
| id | doaj.art-e8cfd7873f9142af9b74c3a1cfa6db65 |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2025-03-14T02:06:34Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-e8cfd7873f9142af9b74c3a1cfa6db652025-03-12T05:49:11ZengWileyMedComm2688-26632022-12-0134n/an/a10.1002/mco2.173Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapySu Zhang0Yang Meng1Lian Zhou2Lei Qiu3Heping Wang4Dan Su5Bo Zhang6Kui‐Ming Chan7Junhong Han8Laboratory of Cancer Epigenetics and Genomics Frontiers Science Center for Disease‐Related Molecular Network State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu ChinaLaboratory of Cancer Epigenetics and Genomics Frontiers Science Center for Disease‐Related Molecular Network State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu ChinaLaboratory of Cancer Epigenetics and Genomics Frontiers Science Center for Disease‐Related Molecular Network State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu ChinaLaboratory of Cancer Epigenetics and Genomics Frontiers Science Center for Disease‐Related Molecular Network State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu ChinaDepartment of Neurosurgery Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaLaboratory of Cancer Epigenetics and Genomics Frontiers Science Center for Disease‐Related Molecular Network State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu ChinaLaboratory of Cancer Epigenetics and Genomics Department of Gastrointestinal Surgery Frontiers Science Center for Disease‐Related Molecular Network West China Hospital Sichuan University Chengdu ChinaDepartment of Biomedical Sciences City University of Hong Kong Hong Kong ChinaLaboratory of Cancer Epigenetics and Genomics Frontiers Science Center for Disease‐Related Molecular Network State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu ChinaAbstract Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been known that autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses, leading to excessive and uncontrol tissue inflammation. The dysregulation of epigenetic alterations including DNA methylation, posttranslational modifications to histone proteins, and noncoding RNA expression has been implicated in a host of inflammatory disorders and the immune system. The inflammatory response is considered as a critical trigger of epigenetic alterations that in turn intercede inflammatory actions. Thus, understanding the molecular mechanism that dictates the outcome of targeting epigenetic regulators for inflammatory disease is required for inflammation resolution. In this article, we elucidate the critical role of the nuclear factor‐κB signaling pathway, JAK/STAT signaling pathway, and the NLRP3 inflammasome in chronic inflammatory diseases. And we formulate the relationship between inflammation, coronavirus disease 2019, and human cancers. Additionally, we review the mechanism of epigenetic modifications involved in inflammation and innate immune cells. All that matters is that we propose and discuss the rejuvenation potential of interventions that target epigenetic regulators and regulatory mechanisms for chronic inflammation‐associated diseases to improve therapeutic outcomes.https://doi.org/10.1002/mco2.173epigenetic regulatorimmuneinflammationposttranslational modification (PTM) |
| spellingShingle | Su Zhang Yang Meng Lian Zhou Lei Qiu Heping Wang Dan Su Bo Zhang Kui‐Ming Chan Junhong Han Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy MedComm epigenetic regulator immune inflammation posttranslational modification (PTM) |
| title | Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy |
| title_full | Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy |
| title_fullStr | Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy |
| title_full_unstemmed | Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy |
| title_short | Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy |
| title_sort | targeting epigenetic regulators for inflammation mechanisms and intervention therapy |
| topic | epigenetic regulator immune inflammation posttranslational modification (PTM) |
| url | https://doi.org/10.1002/mco2.173 |
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