Dimethyl 2-(1-Methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)malonate
In this work we report a facile access to a 3,3-disubstituted isobenzofuranone by tandem addition/cyclization reaction to methyl 2-acetylbenzoate in the presence of dimethyl malonate, under basic conditions.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Molbank |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-8599/2020/2/M1124 |
| _version_ | 1797571360874037248 |
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| author | Antonia Di Mola Rosanna Filosa Antonio Massa |
| author_facet | Antonia Di Mola Rosanna Filosa Antonio Massa |
| author_sort | Antonia Di Mola |
| collection | DOAJ |
| description | In this work we report a facile access to a 3,3-disubstituted isobenzofuranone by tandem addition/cyclization reaction to methyl 2-acetylbenzoate in the presence of dimethyl malonate, under basic conditions. |
| first_indexed | 2024-03-10T20:39:20Z |
| format | Article |
| id | doaj.art-e8d01af8c2b149dcbeb41a9653c5a782 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-10T20:39:20Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-e8d01af8c2b149dcbeb41a9653c5a7822023-11-19T20:50:11ZengMDPI AGMolbank1422-85992020-04-0120202M112410.3390/M1124Dimethyl 2-(1-Methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)malonateAntonia Di Mola0Rosanna Filosa1Antonio Massa2Dipartimento di Chimica e Biologia “A. Zambelli”, Università degli studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, ItalyConsorzio Interuniversitario Sannio Tech., Piazza San G. Moscati 8, SS Appia km 256, 82030 Apollosa, ItalyDipartimento di Chimica e Biologia “A. Zambelli”, Università degli studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, ItalyIn this work we report a facile access to a 3,3-disubstituted isobenzofuranone by tandem addition/cyclization reaction to methyl 2-acetylbenzoate in the presence of dimethyl malonate, under basic conditions.https://www.mdpi.com/1422-8599/2020/2/M1124phthalideisobenzofuranonequaternary carboncascade reactions |
| spellingShingle | Antonia Di Mola Rosanna Filosa Antonio Massa Dimethyl 2-(1-Methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)malonate Molbank phthalide isobenzofuranone quaternary carbon cascade reactions |
| title | Dimethyl 2-(1-Methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)malonate |
| title_full | Dimethyl 2-(1-Methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)malonate |
| title_fullStr | Dimethyl 2-(1-Methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)malonate |
| title_full_unstemmed | Dimethyl 2-(1-Methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)malonate |
| title_short | Dimethyl 2-(1-Methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)malonate |
| title_sort | dimethyl 2 1 methyl 3 oxo 1 3 dihydroisobenzofuran 1 yl malonate |
| topic | phthalide isobenzofuranone quaternary carbon cascade reactions |
| url | https://www.mdpi.com/1422-8599/2020/2/M1124 |
| work_keys_str_mv | AT antoniadimola dimethyl21methyl3oxo13dihydroisobenzofuran1ylmalonate AT rosannafilosa dimethyl21methyl3oxo13dihydroisobenzofuran1ylmalonate AT antoniomassa dimethyl21methyl3oxo13dihydroisobenzofuran1ylmalonate |