Atypical presentation of Paget's disease with secondary osteomyelitis of mandible
Paget's disease (PD) is a chronic progressive disease of the bone characterized by abnormal bone resorption and deposition affecting either single bone (monostotic) or many bones (polyostotic). The precise etiology of the disease is unknown but it is likely that the disease is a result of a vir...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
| Subjects: | |
| Online Access: | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2017;volume=29;issue=3;spage=227;epage=230;aulast=Jayachandran |
| _version_ | 1818280358555156480 |
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| author | Sadaksharam Jayachandran Ramiah Vasudevi Luis Kayal |
| author_facet | Sadaksharam Jayachandran Ramiah Vasudevi Luis Kayal |
| author_sort | Sadaksharam Jayachandran |
| collection | DOAJ |
| description | Paget's disease (PD) is a chronic progressive disease of the bone characterized by abnormal bone resorption and deposition affecting either single bone (monostotic) or many bones (polyostotic). The precise etiology of the disease is unknown but it is likely that the disease is a result of a viral infection of the osteoclasts in a genetically susceptible host. It is inherited as an autosomal dominant trait with high penetrance. The patients affected are usually over forty years of age, and disease is often asymptomatic. The diagnosis is mainly based on biochemical markers of bone turnover and radiological examinations. Normal levels of calcium phosphates and markedly elevated serum alkaline phosphatase (SAP) is a constant feature of this disease. It is regarded as uncommon in Asians, Scandinavians, and black Africans. In India, Paget's disease is rare. Here, we report a rare case of PD with secondary osteomyelitis of mandible with biochemical, radiological, and dual X-ray absortiometry findings. The patient is currently undergoing treatment successfully using bisphosphonates (Alendronate), an anti-resorptive drug to decrease the morbidity associated with the disease. |
| first_indexed | 2024-12-12T23:47:57Z |
| format | Article |
| id | doaj.art-e8d53a2046944666a14c605b5ede7bf6 |
| institution | Directory Open Access Journal |
| issn | 0972-1363 |
| language | English |
| last_indexed | 2024-12-12T23:47:57Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Academy of Oral Medicine and Radiology |
| spelling | doaj.art-e8d53a2046944666a14c605b5ede7bf62022-12-22T00:06:48ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13632017-01-0129322723010.4103/jiaomr.jiaomr_54_17Atypical presentation of Paget's disease with secondary osteomyelitis of mandibleSadaksharam JayachandranRamiah VasudeviLuis KayalPaget's disease (PD) is a chronic progressive disease of the bone characterized by abnormal bone resorption and deposition affecting either single bone (monostotic) or many bones (polyostotic). The precise etiology of the disease is unknown but it is likely that the disease is a result of a viral infection of the osteoclasts in a genetically susceptible host. It is inherited as an autosomal dominant trait with high penetrance. The patients affected are usually over forty years of age, and disease is often asymptomatic. The diagnosis is mainly based on biochemical markers of bone turnover and radiological examinations. Normal levels of calcium phosphates and markedly elevated serum alkaline phosphatase (SAP) is a constant feature of this disease. It is regarded as uncommon in Asians, Scandinavians, and black Africans. In India, Paget's disease is rare. Here, we report a rare case of PD with secondary osteomyelitis of mandible with biochemical, radiological, and dual X-ray absortiometry findings. The patient is currently undergoing treatment successfully using bisphosphonates (Alendronate), an anti-resorptive drug to decrease the morbidity associated with the disease.http://www.jiaomr.in/article.asp?issn=0972-1363;year=2017;volume=29;issue=3;spage=227;epage=230;aulast=JayachandranAlendronatebisphosphonatescotton wool appearanceosteitis deformansserum alkaline phosphatase |
| spellingShingle | Sadaksharam Jayachandran Ramiah Vasudevi Luis Kayal Atypical presentation of Paget's disease with secondary osteomyelitis of mandible Journal of Indian Academy of Oral Medicine and Radiology Alendronate bisphosphonates cotton wool appearance osteitis deformans serum alkaline phosphatase |
| title | Atypical presentation of Paget's disease with secondary osteomyelitis of mandible |
| title_full | Atypical presentation of Paget's disease with secondary osteomyelitis of mandible |
| title_fullStr | Atypical presentation of Paget's disease with secondary osteomyelitis of mandible |
| title_full_unstemmed | Atypical presentation of Paget's disease with secondary osteomyelitis of mandible |
| title_short | Atypical presentation of Paget's disease with secondary osteomyelitis of mandible |
| title_sort | atypical presentation of paget s disease with secondary osteomyelitis of mandible |
| topic | Alendronate bisphosphonates cotton wool appearance osteitis deformans serum alkaline phosphatase |
| url | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2017;volume=29;issue=3;spage=227;epage=230;aulast=Jayachandran |
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